Yanbin Ji, Ph.D.

Research Associate
Center for Craniofacial Molecular Biology
Herman Ostrow School of Dentistry of USC

2250 Alcazar St.
CSA 140 – HSC 9062
Los Angeles, CA 90033-9062
Phone: (323) 442-2837
Fax: (323) 442-2981
yanbinji@usc.edu

Education
Experience
Publications

Datong Medical College, China
M.D., 1981
Medicine

Shanxi Medical University, China
M.S., 1989
Biochemistry

Heinrich Heine University Düsseldorf, Germany
M.D., 1996
Biochemistry

  • 2021 – present – Research Associate – Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA
  • 2010 – 2021 – Research Associate – University of Southern California, Los Angeles, CA
  • 1999 – 2010 – Research Associate – Queen’s University, Kingston, Canada
  • 1998 – 1999 – Postdoc. – University of Iowa
  • 1996 – 1998 – Postdoc. – Iowa State University
  • 1989 – 1994 – Physician/instructor – The 2nd Teaching Hospital of Shanxi Medical University
  • 1981 – 1986 – Hospital of Shengtou Power Plant

  1. Horie M, Castaldi A, Sunohara M, Wang H, Ji Y, Liu Y, Li F, Wilkinson TA, Hung L, Shen H, Kage H, Offringa IA, Marconett CN, Flodby P, Zhou B, Borok Z. (2020) Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker. Cells. 2020 Nov 11;9(11):2460. doi: 10.3390/cells9112460. PMID:33187367; PMCID: PMC7697677.

  2. Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall ED. (2016) Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol. 2016 Sep;55(3):395-406. doi: 10.1165/rcmb.2016-0005OC. PMID: 27064541; PMCID: PMC5023030.

  3. Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z. (2014) Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug;51(2):210-22. doi: 10.1165/rcmb.2013-0353OC. PMID: 24588076; PMCID: PMC4148039.

  4. Ji Y, Majumder S, Millard M, Borra R, Bi T, Elnagar AY, Neamati N, Shekhtman A, Camarero JA. (2013) In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide. J Am Chem Soc. 2013 Aug 7;135(31):11623-11633. doi: 10.1021/ja405108p. Epub 2013 Jul 25. PMID: 23848581; PMCID: PMC3767463.

  5. D Souza Y, Ji Y, Bennett BM. (2013) Effect of overexpression of human aldehyde dehydrogenase 2 in LLC-PK1 cells on glyceryl trinitrate biotransformation and cGMP accumulation. Br J Pharmacol. 2013 Feb;168(4):978-87. doi:10.1111/j.1476-5381.2012.02220.x. PMID: 22994391; PMCID: PMC3631385.

  6. Gould A, Ji Y, Aboye TL, Camarero JA. (2011) Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery. Curr Pharm Des. 2011 Dec;17(38):4294-307. doi: 10.2174/138161211798999438. PMID: 22204428; PMCID: PMC3330703.

  7. Ji Y, Anderson DJ, Bennett BM. (2009) Role of microsomal glutathione transferase 1 in the mechanism-based biotransformation of glyceryl trinitrate in LLC-PK1 cells. Biochem Pharmacol. 2009 Jun 1;77(11):1702-8. doi:10.1016/j.bcp.2009.02.022. Epub 2009 Mar 11. PMID: 19428324.

  8. Nicolescu AC, Ji Y, Comeau JL, Hill BC, Takahashi T, Brien JF, Racz WJ, Massey TE. (2008) Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells. Toxicol Appl Pharmacol. 2008 Mar 15;227(3):370-9. doi:10.1016/j.taap.2007.12.009. Epub 2007 Dec 15. PMID: 18191165.

  9. Kinobe RT, Ji Y, Vlahakis JZ, Motterlini R, Brien JF, Szarek WA, Nakatsu K. (2007) Effectiveness of novel imidazole-dioxolane heme oxygenase inhibitors in renal proximal tubule epithelial cells. J Pharmacol Exp Ther. 2007 Dec;323(3):763-70. doi: 10.1124/jpet.107.119800. Epub 2007 Aug 30. PMID: 17761847.

  10. Ji Y, Bennett BM. (2006) Biotransformation of glyceryl trinitrate by rat hepatic microsomal glutathione S-transferase 1. J Pharmacol Exp Ther. 2006 Sep;318(3):1050-6. doi: 10.1124/jpet.106.103713. Epub 2006 May 23. PMID: 16720755.

  11. Ji Y, Neverova I, Van Eyk JE, Bennett BM. (2006) Nitration of tyrosine 92 mediates the activation of rat microsomal glutathione s-transferase by peroxynitrite. J Biol Chem. 2006 Jan 27;281(4):1986-91. doi: 10.1074/jbc.M509480200. Epub 2005 Nov 28. PMID: 16314419.

  12. Green CR, Kobus SM, Ji Y, Bennett BM, Reynolds JN, Brien JF. (2005) Chronic prenatal ethanol exposure increases apoptosis in the hippocampus of the term fetal guinea pig. Neurotoxicol Teratol. 2005 Nov-Dec;27(6):871-81. doi:10.1016/j.ntt.2005.07.006. Epub 2005 Aug 19. Erratum in: Neurotoxicol Teratol.2006 Mar-Apr;28(2):296-7. PMID: 16112842.

  13. Kinobe R, Ji Y, Nakatsu K. (2004) Peroxynitrite-mediated inactivation of heme oxygenases. BMC Pharmacol. 2004 Oct 21;4:26. doi: 10.1186/1471-2210-4-26. PMID:15498099; PMCID: PMC529254.

  14. DiFabio J, Ji Y, Vasiliou V, Thatcher GR, Bennett BM. (2003) Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance. Mol Pharmacol. 2003 Nov;64(5):1109-16. doi: 10.1124/mol.64.5.1109. PMID: 14573760.

  15. Ji Y, Bennett BM. (2003) Activation of microsomal glutathione s-transferase by peroxynitrite. Mol Pharmacol. 2003 Jan;63(1):136-46. doi: 10.1124/mol.63.1.136. PMID: 12488546.

  16. Ji Y, Toader V, Bennett BM. (2002) Regulation of microsomal and cytosolic glutathione S-transferase activities by S-nitrosylation. Biochem Pharmacol. 2002 Apr 15;63(8):1397-404. doi: 10.1016/s0006-2952(02)00879-1. PMID: 11996880.

  17. Ji Y, Akerboom TP, Sies H, Thomas JA. (1999) Gel electrofocusing method for studying protein S-nitrosylation. Methods Enzymol. 1999;301:145-51. doi:10.1016/s0076-6879(99)01077-0. PMID: 9919562.

  18. Ji Y, Akerboom TP, Sies H, Thomas JA. (1999) S-nitrosylation and S-glutathiolation of protein sulfhydryls by S-nitroso glutathione. Arch Biochem Biophys. 1999 Feb 1;362(1):67-78. doi: 10.1006/abbi.1998.1013. PMID: 9917330.

  19. Sies H, Dafré AL, Ji Y, Akerboom TP. (1998) Protein S-thiolation and redox regulation of membrane-bound glutathione transferase. Chem Biol Interact. 1998 Apr 24;111-112:177-85. doi: 10.1016/s0009-2797(97)00160-9. PMID: 9679553.

  20. Akerboom TP, Ji Y, Wagner G, Sies H. (1997) Subunit specificity and organ distribution of glutathione transferase-catalysed S-nitrosoglutathione formation from alkyl nitrites in the rat. Biochem Pharmacol. 1997 Jan 10;53(1):117-20. doi: 10.1016/s0006-2952(96)00602-8. PMID: 8960071.

  21. Ji Y, Akerboom TP, Sies H. (1996) Microsomal formation of S-nitrosoglutathione from organic nitrites: possible role of membrane-bound glutathione transferase. Biochem J. 1996 Jan 15;313 ( Pt 2)(Pt 2):377-80. doi: 10.1042/bj3130377. Erratum in: Biochem J 1996 May 1;315(Pt 3):1063. PMID: 8573068; PMCID: PMC1216919.