Welcome
The Herman Ostrow School of Dentistry of USC’s Center for Craniofacial Molecular Biology is a unique facility that unites world-class researchers in a variety of disciplines centered around structures of the craniofacial region. Since its inception in 1991, CCMB has been home to several major discoveries and has attracted top researchers from around the world.
January 20, 2021
New Publications From Chai Lab
Two new manuscripts have been accepted, bringing the Chai Lab annual tally to 10! We are honored. Links to be posted soon.
He, J., Jing, J., Feng, J., Han, X., Yuan, Y., Guo, T., Pei, F., Ma, Y., Cho, C., Ho, T-V., and Chai, Y. (2021) Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning. PLoS Genetics, 17(2):e1009320.
Han, X., Feng, J., Guo, T., Loh, Y-H E., Yuan, Y., Ho, T-V., Cho, C., Li., J., Jing, J., Janeckova, E., He, J., Pei, F., Bi, J., Song, B., and Chai, Y. (2021) Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis. eLife Accepted.
January 7, 2021
New Publication from Chai Lab
Yu et al., develop a platform for cranial suture regeneration using a biodegradable material combined with mesenchymal stem cells in a mouse model of craniosynostosis that reverses increased intracranial pressure, skull and neurocognitive abnormalities.
Yu M, Ma L, Yuan Y, Ye X, Montagne A, He J, Ho TV, Wu Y, Zhao Z, Sta Maria N, Jacobs R, Urata M, Wang H, Zlokovic BV, Chen JF, Chai Y. (2021) Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis. Cell. 2021 Jan 7; 184 (1): doi: doi.org/10.1016/j.cell.2020.11.037
Read Herman Ostrow School of Dentistry at USC piece on this publication here.
December 30, 2020
New publication from Chai Lab
Jing J, Feng J, Li J, Zhao H, Ho T, He J, Yuan Y, Guo T, Du J, Urata M, Sharpe P, Chai Y. (2020) Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis. eLife, Accepted.