Tingwei Guo, Ph.D.

Tingwei Guo

Research Scientist, Team Lead
Center for Craniofacial Molecular Biology
Herman Ostrow School of Dentistry of USC

2250 Alcazar St.
CSA 146 – HSC 9062
Los Angeles, CA 90033-9062
Phone: (323) 442-3191
Fax: (323) 442-2981
tingweig@usc.edu

Education
Experience
Publications

Pittsburg State University, Pittsburg, Kansas
B.S., 2008
Stomatology

Pittsburg State University, Pittsburg, Kansas
M.S., 2011
Cell and Molecular Biology

University of Alabama, Tuscaloosa, Alabama
Ph.D., 2018
Cellular, Molecular, and Genetics

  • 2024 – present – Research Scientist, Team Lead – Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA
  • 2023 – 2024 – Research Associate – Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA
  • 2018 – 2023 – Postdoctoral Scholar – Research Associate – Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA

  1. Buchanan C, Chen S, Yuan Y, Guo T, Feng J, Zhang M, Carey G, Howard I, Sanchez J, Ho TV, Chai Y. Loss of Runx2 in Gli1+ osteogenic progenitors prevents bone loss following ovariectomy. JBMR Plus, Volume 9, Issue 1, January 2025, ziae141, https://doi.org/10.1093/jbmrpl/ziae141.

  2. Pei F, Guo T, Zhang M, Ma L, Jing J, Feng J, Ho T-V, Wen Q, Chai Y. FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development. Bone Res 12, 37 (2024). https://doi.org/10.1038/s41413-024-00345-5.

  3. Zhang M, Guo T, Pei F, Feng J, Jing J, Xu J, Yamada T, Ho T-V, Du J, Sehgal P, Chai Y. ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling. Nat Commun 15, 4614 (2024). https://doi.org/10.1038/s41467-024-48285-2.

  4. Guo T, Pei F, Zhang M, Yamada T, Feng J, Jing J, Ho T-V, Chai Y. Vascular architecture regulates mesenchymal stromal cell heterogeneity via p53-PDGF signaling in the mouse incisor. Cell Stem Cell. 2024 May 03. https://doi.org/10.1016/j.stem.2024.04.011.

  5. Pei F, Ma L, Guo T, Zhang M, Jing J, Wen Q, Feng J, Lei J, He J, Janečková E, Ho TV, Chen JF, Chai Y. Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis. Development. 2024 Jan 15;151(2):dev202043. doi: 10.1242/dev.202043. Epub 2024 Jan 11. PMID: 38108472.

  6. Janečková E, Feng J, Guo T, Han X, Ghobadi A, Araujo-Villalba A, Rahman MS, Ziaei H, Ho TV, Pareek S, Alvarez J, Chai Y. Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis. Development. 2023 Mar 1;150(5):dev201189. doi: 10.1242/dev.201189. Epub 2023 Mar 9. PMID: 36825984; PMCID: PMC10108707.

  7. Jing J, Zhang M, Guo T, Pei F, Yang Y, and Chai Y. (2022) Rodent incisor as a model to study mesenchymal stem cells in tissue homeostasis and repair. Front. Dent. Med, 30 November 2022, Volume 3 – 2022. https://doi.org/10.3389/fdmed.2022.1068494

  8. Feng J, Han X, Yuan Y, Cho CK, Janečková E, Guo T, Pareek S, Rahman MS, Zheng B, Bi J, Jing J, Zhang M, Xu J, Ho TV, Chai Y. TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. eLife. 2022 Dec 21;11:e80405. doi: 10.7554/eLife.80405. PMID: 36542062; PMCID: PMC9771365. 

  9. Jing J, Feng J, Yuan Y, Guo T, Lei J, Pei F, Ho TV, Chai Y. Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 2022 Aug 16;13(1):4803. doi: 10.1038/s41467-022-32490-y. PMID: 35974052; PMCID: PMC9381504. 

  10. Guo T, Han X, He J, Feng J, Jing J, Janeckova E, Lei J, Ho T-V, Xu J, Chai Y. (2022) KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. eLife. 2022 Feb 25;11:e74595. doi: 10.7554/eLife.74595. PMID: 35212626; PMCID: PMC9007587.

  11. Jing J, Feng J, Li J, Zhao H, Ho TV, He J, Yuan Y, Guo T, Du J, Urata M, Sharpe P, Chai Y. (2021) Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis. eLife. 2021 Jan22;10:e59459. doi: 10.7554/eLife.59459. PMID: 33480845; PMCID: PMC7822593.

  12. Han X, Feng J, Guo T, Loh YE, Yuan Y, Ho TV, Cho CK, Li J, Jing J, Janeckova E, He J, Pei F, Bi J, Song B, Chai Y. (2021) Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis. eLife. 2021 Jan 22;10:e62387. doi: 10.7554/eLife.62387. PMID: 33482080; PMCID: PMC7826157.

  13. He J, Jing J, Feng J, Han X, Yuan Y, Guo T, Pei F, Ma Y, Cho C, Ho TV, Chai Y. (2021) Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning. PLoS Genet. 2021 Feb 17;17(2):e1009320. doi: 10.1371/journal.pgen.1009320. PMID: 33596195; PMCID: PMC7920342.

  14. Lei J, Chen S, Jing J, Guo T, Feng J, Ho TV, Chai Y. (2021) Inhibiting Hh signaling in Gli1+ osteogenic progenitors alleviates TMJOA. J Dent Res. 2022 Jun;101(6):664-674. doi: 10.1177/00220345211059079. Epub 2022 Jan 20. PMID: 35045740; PMCID: PMC9124909.