Qing Chang, M.S.

Research Assistant
Center for Craniofacial Molecular Biology
Herman Ostrow School of Dentistry of USC

2250 Alcazar St.
CSC 121 – HSC 9062
Los Angeles, CA 90033-9062
Phone: (323) 442-3187
Fax: (323) 442-2981
qingc@usc.edu

Education
Experience
Publications

University of Southern California, Los Angeles, California
M.S., 2021
Molecular Microbiology and Immunology 

Shanghai Jiao Tong University (SJTU), Shangai, China
M.S., 2017
Medicine in Internal Medicine

Nanjing Medical University (NJMU), Nanjing, China
B.S., 2015
Clinical Medicine

  • 2022 – present – Research Assistant – Center for Craniofacial Molecular Biology – University of Southern California, Los Angeles, CA

  1. Zhang W, Zhang M, Ma L, Jariyasakulroj S, Chang Q, Lin Z, Lu Z, Chen JF. Impaired phase separation and nucleolar functions in hiPSC models of SNORD118-related ribosomopathies. iScience, Volume 27, Issue 8, 2024, 110430, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2024.110430.

  2. Zhang W, Zhang M, Ma L, Jariyasakulroj S, Chang Q, Lin Z, Lu Z, Chen JF. Recapitulating and reversing human brain ribosomopathy defects via the maladaptive integrated stress response. Sci Adv. 2024 Feb 2;10(5):eadk1034. doi: 10.1126/sciadv.adk1034. Epub 2024 Feb 2. PMID: 38306425; PMCID: PMC10836730.

  3. Ma L, Wang F, Li Y, Wang J, Chang Q, Du Y, Sadan J, Zhao Z, Fan G, Yao B, Chen JF. (2023) Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation. Nat Commun. 2023 Nov 29;14(1):7829. doi: 10.1038/s41467-023-43497-4. PMID: 38030616; PMCID: PMC10687003

  4. Ma L, Chang Q, Pei F, Liu M, Zhang W, Hong YK, Chai Y, Chen JF. Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis. Cell Stem Cell. 2023 Nov 2;30(11):1472-1485.e7. doi: 10.1016/j.stem.2023.09.012. Epub 2023 Oct 19. PMID: 37863055; PMCID: PMC10842404.

  5. Ma L, Liang C, Wang J, Chang Q, Wang Y, Zhang W, Du Y, Sadan J, Chen JF. (2022) Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors. Human Molecular Genetics, accepted.

  6. Chen Liang, Qiang Shao, Wei Zhang, Mei Yang, Qing Chang, Rong Chen, Jian-Fu Chen. (2019) Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models. Human Molecular Genetics, Volume 28, Issue 23, 1 December 2019, Pages 3940–3953, https://doi.org/10.1093/hmg/ddz230.

  7. Herrlinger S, Shao Q, Yang M, Chang Q, Liu Y, Pan X, Yin H, Xie LW, Chen JF. (2019) Lin28-mediated temporal promotion of protein synthesis is crucial for neural progenitor cell maintenance and brain development in mice. Development. 2019 May 28;146(10). pii: dev173765. doi: 10.1242/dev.173765.

  8. Shao Q, Liang C, Chang Q, Zhang W, Yang M, Chen JF. (2019) C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent. Acta Neuropathol Commun. 2019 Mar 4;7(1):32. doi:10.1186/s40478-019-0685-7.

  9. Zhang ZZ, Cheng YW, Jin HY, Chang Q, Shang QH, Xu YL, Chen LX, Xu R, Song B, Zhong JC. (2017) The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling. Oncotarget. 2017 Aug 17;8(42):72302-72314. doi: 10.18632/oncotarget.20305. eCollection 2017 Sep 22.

  10. Hu D, Lin X, Chen Y, Chang Q, Chen G, Li C, Zhang H, Cui Z, Liang B, Jiang W, Ji K, Huang J, Peng F, Zheng X, Niu W. (2017) Preoperative blood-routine markers and prognosis of esophageal squamous cell carcinoma: The Fujian prospective investigation of cancer (FIESTA) study. Oncotarget. 2017 Apr 4;8(14):23841-23850. doi: 10.18632/oncotarget.13318.

  11. Xu R, Zhang ZZ, Chen LJ, Yu HM, Guo SJ, Xu YL, Oudit GY, Zhang Y, Chang Q, Song B, Chen DR, Zhu DL, Zhong JC. (2016) Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-β-catenin signaling. Peptides. 2016 Dec;86:85-94. doi: 10.1016/j.peptides.2016.10.005. Epub 2016 Oct 20. PMID: 27773659.

  12. Chen LJ, Xu YL, Song B, Yu HM, Oudit GY, Xu R, Zhang ZZ, Jin HY, Chang Q, Zhu DL, Zhong JC. (2016) Angiotensin-converting enzyme 2 ameliorates renal fibrosis by blocking the activation of mTOR/ERK signaling in apolipoprotein E-deficient Peptides. 2016 May;79:49-57. doi: 10.1016/j.peptides.2016.03.008. Epub 2016 Mar 24.

  13. Chen LJ, Xu R, Yu HM, Chang Q, Zhong JC. (2015) The ACE2/Apelin Signaling, MicroRNAs, and Hypertension. Int J Hypertens. 2015;2015:896861. doi: 10.1155/2015/896861. Epub 2015 Mar 1.