Malcolm Snead, D.D.S., Ph.D.

Malcolm Snead

Professor
Herman Ostrow School of Dentistry of USC

 

2250 Alcazar St.
CSA 142 – HSC 9062
Los Angeles, CA 90089
Phone: (323) 442-3178
Fax: (323) 442-2981
mlsnead@usc.edu


Education
Experience
Awards
Research
Publications

St. Mary’s College, Moraga, CA
B.S., 1973
Biology/Chemistry

Loyola University, College of Dental Surgery, Chicago, IL
D.D.S., 1977
Dentistry

The University of Chicago, Chicago, IL
Certificate, 1979
Oral Pathology

The University of Chicago, Chicago, IL
Ph.D., 1981
Pathology

  • 2012 – 2022 – Chair – Division of Biomedical Sciences, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA
  • 1997 – Present – Professor – Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1992 – 1997 – Associate Professor – Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1984 – 1992 – Research Assistant Professor & Research Associate Professor – Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1982 – 1984 – Postdoctoral Trainee, Dr. H.C. Slavkin, Craniofacial Biology – Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
  • 1981 – 1982 – Postdoctoral Trainee, Dr. Savio L.C. Woo – Baylor College of Medicine, Hughes Medical Research Institute, Houston, Texas
  • 1977 – 1981 – Research Associate, Zoller Dental Clinic – The University of Chicago, Chicago, IL
  • 2017 – Doctor Honaris Causa, University of Oslo, Norway
  • 2017 – Fellow, American Institute for Medical and Biomedical Engineering
  • 2010 – Recipient, Mellon Faculty Mentoring Award, University of Southern California
  • 2007 – Fulbright Senior Specialist Award, US Embassy (University of the Witwatersrand, South Africa)
  • 2001 – Research in Oral Biology Award, International Association for Dental Research
  • 2000 – MERIT Award, NIH, National Institute for Dental and Craniofacial Research
  • 1995 – Fellow, American Association for the Advancement of Science
  • 1988 – Dana-Farber Computer Resource Center Fellowship
  • 1985-1990 – Research Career Development Award, USPHS, NIH, NIDR
  • 1977-1981 – Walter G. Zoller Fellow, The University of Chicago
  • 1976-1977 – Johnson and Johnson Fellow

Peptide Enabled Tunable Restorative Interface – Grant # R56 DE032903

  • Principal Investigator: Candan Tamerler, PhD
  • Sponsor: NIH
  • Period: 09/01/2023-08/31/2024
  • Goal: To engineer multifunctional peptide-polymer adhesives that work synergistically with SDF to arrest caries and promote tooth remineralization, while inhibiting the stigmatizing side effect of black staining.

Supramolecular nanofibers for recombinant growth factor-free spine fusion – Grant #5 R01 AR072721 (60050309 USC)

  • Principal Investigator: Malcolm L. Snead, D.D.S, Ph.D.
  • Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • Period: 07/12/2018-04/30/2024
  • Goal: To develop a highly effective strategy to regenerate bone using recombinant growth factor-free bioactive nanoscale materials, suitable to spine fusion and other orthopaedic applications. The nanofiber scaffold developed in this work will be used either on its own or in combination with bone marrow stromal cells (BMSC) rather than with recombinant growth factor. Such an approach could obviate the need for recombinant factors, thereby providing a safer and more effective therapeutic strategy for bone regeneration in spinal fusion and other orthopaedic applications.

Multispecies biofilm for investigate non-antibiotic therapies in dentistry (MISFAITH) – Project Number: 015562-00001

  • Principal Investigator: Malcolm L. Snead, D.D.S, Ph.D.
  • Sponsor: The Research Council of Norway, University of Oslo
  • Period: 09/01/2022-08/31/2027
  • Goal: This project is to provide knowledge and laboratory advances including several nano-biotechnologies to address peri-implant disease. These include identification and refinement of small peptides (6-10 amino acids) that demonstrate high affinity and selectivity for binding to the atomic face of titanium and Ti-alloys used in implants. Titanium binding peptides (TiBP) can be chemically synthesized and can be made to include a second bioactive molecule, producing a bifunctional peptide, that binds only to the implant surface to deliver a bioactive signal to the host.

  1. Boone K, Tjokro N, Chu KN, Chen C, Snead ML, Tamerler C. Machine learning enabled design features of antimicrobial peptides selectively targeting peri-implant disease progression. Front Dent Med. 2024;5:1372534. doi: 10.3389/fdmed.2024.1372534. Epub 2024 Apr 5. PMID: 38846578; PMCID: PMC11155447.

  2. Zhou Y, Fyrner T, Chen, CH, Sather NA, Hsu EL, Stupp SI, Snead ML. (2023) Optimization of peptide amphiphile-lipid raft interaction by changing peptide amphiphile lipophilicity. Acta Biomaterialia, Volume 164, 2023, Pages 377-386, ISSN 1742-7061, https://doi.org/10.1016/j.actbio.2023.04.004.

  3. Cloyd AK, Boone K, Ye Q, Snead ML, Spencer P, Tamerler C. (2023) Engineered Peptides Enable Biomimetic Route for Collagen Intrafibrillar Mineralization. Int J Mol Sci. 2023 Mar 28;24(7):6355. doi: 10.3390/ijms24076355. PMID: 37047325; PMCID: PMC10093982.

  4. Woolfolk SK, Cloyd AK, Ye Q, Boone K, Spencer P, Snead ML, Tamerler C. (2022) Peptide-Enabled Nanocomposites Offer Biomimetic Reconstruction of Silver Diamine Fluoride-Treated Dental Tissues. Polymers (Basel). 2022 Mar 28;14(7):1368. doi: 10.3390/polym14071368. PMID: 35406242; PMCID: PMC9002525.

  5. Geng S, Lei Y, Snead ML. (2021) Minimal amelogenin domain for enamel formation. JOM(1989). 2021 Jun;73(6):1696-1704. doi: 10.1007/s11837-021-04687-x. Epub 2021 May 7. PMID: 34456537; PMCID: PMC8386916.

  6. Ruspita I, Das P, Xia Y, Kelangi S, Miyoshi K, Noma T, Snead ML, D’Souza RN, Bei M. (2020) An Msx2-Sp6-Follistatin Pathway Operates During Late Stages of Tooth Development to Control Amelogenesis. Front Physiol. 2020 Oct 26;11:582610. doi: 10.3389/fphys.2020.582610. PMID: 33192593; PMCID: PMC7649293.

  7. Wisdom EC, Zhou Y, Chen C, Tamerler C, Snead ML. (2020) Mitigation of peri-implantitis by rational design of bifunctional peptides with antimicrobial properties. ACS Biomater Sci Eng. 2020 May 11;6(5):2682-2695. doi: 10.1021/acsbiomaterials.9b01213. Epub 2019 Sep 24. PMID: 32467858; PMCID: PMC7255409.

  8. Sharma A, Snead ML, Katti K, Katti D.(2019) Mechanics of Amelogenin TRAP protein in the Proximity of Hydroxyapatite Mineral id Altered by Interfacial Water. Chemical Physics, 522:104-111, 2019, https://doi.org/10.1016/j.chemphys.2019.02.017.

  9. Wisdom C, Chen C, Yuca E, Zhou Y, Tamerler C, Snead ML. (2019) Repeatedly Applied Peptide Film Kills Bacteria on Dental Implants. JOM (1989). 2019 Apr;71(4):1271-1280. doi: 10.1007/s11837-019-03334-w. Epub 2019 Jan 18. PubMed PMID: 31178649; PubMed Central PMCID: PMC6550465.

  10. Nirvani M, Khuu C, Tulek A, Utheim TP, Sand LP, Snead ML, Sehic A. (2019) Transcriptomic analysis of MicroRNA expression in enamel-producing cells. Gene. 2019 Mar 10;688:193-203. doi: 10.1016/j.gene.2018.11.089. Epub 2018 Dec 5. PubMed PMID: 30529249.

  11. Wang P, Gao J, Wang D, Snead ML, Li J, Ruan J. (2017) Optimizing concentration of titanium tetrafluoride solution for human dentine remineralization. Arch Oral Biol. 2017 Jul 1;83:7-12. doi: 10.1016/j.archoralbio.2017.06.021. [Epub ahead of print] PubMed PMID: 28689018.

  12. Yin K, Lin W, Guo J, Sugiyama T, Snead ML, Hacia JG, Paine ML. (2017) MiR-153 Regulates Amelogenesis by Targeting Endocytotic and Endosomal/lysosomal Pathways-Novel Insight into the Origins of Enamel Pathologies. Sci Rep. 2017 Mar 13;7:44118. doi: 10.1038/srep44118. PubMed PMID: 28287144; PubMed Central PMCID: PMC5347039.

  13. Cox BN, Snead ML. (2016) Cells as strain-cued automata. J Mech Phys Solids. 2016 Feb;87:177-226. doi: 10.1016/j.jmps.2015.11.002. Epub 2015 Dec 2. PMID: 31178602; PMCID: PMC6550492.

  14. VanOosten SK, Yuca E, Karaca BT, Boone K, Snead ML, Spencer P, Tamerler C. (2016) Biosilver nanoparticle interface offers improved cell viability. Surf Innov. 2016 Sep;4(3):121-132. doi: 10.1680/jsuin.16.00010. Epub 2016 Nov 7. PubMed PMID: 29057075; PubMed Central PMCID: PMC5650198.

  15. Noh HJ, Koh DI, Lee KO, Jeon BN, Kim MK, Snead ML, Hur MW. (2016) Role of MIZ-1 in AMELX gene expression. Biochem Biophys Rep. 2016 Oct 15;8:340-345. doi: 10.1016/j.bbrep.2016.10.007. eCollection 2016 Dec. PubMed PMID: 28955974; PubMed Central PMCID: PMC5614537.

  16. Zhao L, Li J, Su J, Snead ML, Ruan J. (2016) LS8 cell apoptosis induced by NaF through p-ERK and p-JNK – a mechanism study of dental fluorosis. Acta Odontol Scand. 2016 Oct;74(7):539-549. Epub 2016 Sep 14. PubMed PMID: 27624793.

  17. Wisdom C, VanOosten SK, Boone KW, Khvostenko D, Arnold PM, Snead ML, Tamerler C. (2016) Controlling the Biomimetic Implant Interface: Modulating Antimicrobial Activity by Spacer Design. J Mol Eng Mater. 2016 Mar;4(1). pii: 1640005. doi:10.1142/S2251237316400050. Epub 2016 Aug 22. PubMed PMID: 28936427; PubMed Central PMCID: PMC5604879.

  18. Shen W, Wang Y, Liu Y, Liu H, Zhao H, Zhang G, Snead ML, Han D, Feng H. (2016) Functional Study of Ectodysplasin-A Mutations Causing Non-Syndromic Tooth Agenesis. PLoS One. 2016 May 4;11(5):e0154884. doi: 10.1371/journal.pone.0154884. eCollection 2016. PubMed PMID: 27144394; PubMed Central PMCID: PMC4856323.

  19. Newcomb CJ, Sur S, Lee SS, Yu JM, Zhou Y, Snead ML, Stupp SI. (2016) Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility. Nano Lett. 2016 May 11;16(5):3042-50. doi: 10.1021/acs.nanolett.6b00054. Epub 2016 Apr 12. PubMed PMID: 27070195; PubMed Central PMCID: PMC4948975.

  20. Mounir MM, Matar MA, Lei Y, Snead ML. (2016) Recombinant Amelogenin Protein Induces Apical Closure and Pulp Regeneration in Open-apex, Nonvital Permanent Canine Teeth. J Endod. 2016 Mar;42(3):402-12. doi: 10.1016/j.joen.2015.11.003. Epub 2015 Dec 18. PubMed PMID: 26709200; PubMed Central PMCID: PMC4766029.

  21. Snead ML. (2015) Biomineralization of a self-assembled-, soft-matrix precursor: Enamel. JOM (1989). 2015 Mar 1;67(4):788-795. doi: 10.1007/s11837-015-1305-z. PMID: 26052186; PMCID: PMC4454482.

  22. Huang Z, Newcomb CJ, Lei Y, Zhou Y, Bornstein P, Amendt BA, Stupp SI, Snead ML. (2015) Bioactive nanofibers enable the identification of thrombospondin 2 as a key player in enamel regeneration. Biomaterials. 2015 Aug;61:216-28. doi:10.1016/j.biomaterials.2015.05.035. PubMed PMID: 26004236; PubMed Central PMCID: PMC4467543.

  23. Villa O, Wohlfahrt JC, Mdla I, Petzold C, Reseland JE, Snead ML, Lyngstadaas SP. (2015) Proline-Rich Peptide Mimics Effects of Enamel Matrix Derivative on Rat Oral Mucosa Incisional Wound Healing. J Periodontol. 2015 Dec;86(12):1386-95. doi: 10.1902/jop.2015.150207. Epub 2015 Aug 7. PubMed PMID: 26252748.

  24. Nurbaeva MK, Eckstein M, Snead ML, Feske S, Lacruz RS. (2015) Store-operated Ca2+ Entry Modulates the Expression of Enamel Genes. J Dent Res. 2015 Oct;94(10):1471-7. doi: 10.1177/0022034515598144. Epub 2015 Jul 31. PubMed PMID: 26232387; PubMed Central PMCID: PMC4577984.

  25. Sidaly R, Landin MA, Suo Z, Snead ML, Lyngstadaas SP, Reseland JE. (2015) Hypoxia increases the expression of enamel genes and cytokines in an ameloblast-derived cell line. Eur J Oral Sci. 2015 Jul 20. doi: 10.1111/eos.12201. [Epub ahead of print] PubMed PMID: 26193448.

  26. Geng S, White SN, Paine ML, Snead ML. (2015) Protein Interaction between Ameloblastin and Proteasome Subunit α Type 3 Can Facilitate Redistribution of Ameloblastin Domains within Forming Enamel. J Biol Chem. 2015 Aug 21;290(34):20661-73. doi: 10.1074/jbc.M115.640185. Epub 2015 Jun 12. PubMed PMID: 26070558; PubMed Central PMCID: PMC4543628.

  27. Moshaverinia A, Chen C, Xu X, Ansari S, Zadeh HH, Schricker SR, Paine ML, Moradian-Oldak J, Khademhosseini A, Snead ML, Shi S. (2015) Regulation of the Stem Cell-Host Immune System Interplay Using Hydrogel Coencapsulation System with an Anti-Inflammatory Drug. Adv Funct Mater. 2015 Apr 15;25(15):2296-2307. PubMed PMID: 26120294; PubMed Central PMCID: PMC4478611.

  28. Yucesoy DT, Hnilova M, Boone K, Arnold PM, Snead ML, Tamerler C. (2015) Chimeric peptides as implant functionalization agents for titanium alloy implants with antimicrobial properties. JOM (1989). 2015 Apr;67(4):754-766. PubMed PMID: 26041967; PubMed Central PMCID: PMC4450091.

  29. Zhou Y, Snead ML, Tamerler C. (2015) Bio-inspired hard-to-soft interface for implant integration to bone. Nanomedicine. 2015 Feb;11(2):431-4. doi: 10.1016/j.nano.2014.10.003. Epub 2014 Nov 22. PubMed PMID: 25461292; PubMed Central PMCID: PMC4330108.

  30. Yang T, Zhang Y, Zheng D, Hao Y, Snead ML, Duan X. (2015) High-fluoride promoted phagocytosis-induced apoptosis in a matured ameloblast-like cell line. Arch Oral Biol. 2015 Jan;60(1):84-90. doi: 10.1016/j.archoralbio.2014.09.001. Epub 2014 Sep 17. PubMed PMID: 25260155; PubMed Central PMCID: PMC4469496.

  31. Jang HL, Lee K, Kang CS, Lee HK, Ahn HY, Jeong HY, Park S, Kim SC, Jin K, Park J, Yang TY, Kim JH, Shin SA, Han HN, Oh KH, Lee HY, Lim J, Hong KS, Snead ML, Xu J, Nam KT. (2015) Biofunctionalized ceramic with self-assembled networks of nanochannels. ACS Nano. 2015;9(4):4447-57. doi: 10.1021/acsnano.5b01052. PubMed PMID: 25827409; PubMed Central PMCID: PMC4485927.

  32. Sarkar J, Simanian EJ, Tuggy SY, Bartlett JD, Snead ML, Sugiyama T, Paine ML. (2014) Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. Front Physiol. 2014 Jul 25;5:277. doi: 10.3389/fphys.2014.00277. eCollection 2014. PubMed PMID: 25120490; PubMed Central PMCID: PMC4110967.

  33. Monsarrat P, Vergnes JN, Nabet C, Sixou M, Snead ML, Planat-Bénard V, Casteilla L, Kémoun P. (2014) Concise Review: Mesenchymal Stromal Cells Used for Periodontal Regeneration: A Systematic Review. Stem Cells Transl Med. 2014 Jun;3(6):768-74. doi: 10.5966/sctm.2013-0183. Epub 2014 Apr 17. Review. PubMed PMID: 24744392; PubMed Central PMCID: PMC4039455.

  34. Moshaverinia A, Xu X, Chen C, Ansari S, Zadeh HH, Snead ML, Shi S. (2014) Application of stem cells derived from the periodontal ligament or gingival tissue sources for tendon tissue regeneration. Biomaterials. 2014 Mar;35(9):2642-50. doi:10.1016/j.biomaterials.2013.12.053. Epub 2014 Jan 4. PubMed PMID: 24397989; PubMed Central PMCID: PMC3929697.

  35. Li X, Venugopalan SR, Cao H, Pinho FO, Paine ML, Snead ML, Semina EV, Amendt BA. (2014) A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Hum Mol Genet. 2014 Jan 1;23(1):194-208. doi: 10.1093/hmg/ddt411. Epub 2013 Aug 23. PubMed PMID: 23975681; PubMed Central PMCID: PMC3857954.

  36. Moshaverinia A, Xu X, Chen C, Akiyama K, Snead ML, Shi S. (2013) Dental mesenchymal stem cells encapsulated in an alginate hydrogel co-delivery microencapsulation system for cartilage regeneration. Acta Biomater. 2013 Dec;9(12):9343-50. doi:10.1016/j.actbio.2013.07.023. Epub 2013 Jul 26. PubMed PMID: 23891740; PubMed Central PMCID: PMC3818395.

  37. Moshaverinia A, Ansari S, Chen C, Xu X, Akiyama K, Snead ML, Zadeh HH, Shi S. (2013) Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in alginate microspheres for bone tissue engineering. Biomaterials. 2013 Sep;34(28):6572-9. doi: 10.1016/j.biomaterials.2013.05.048. Epub 2013 Jun 14.PubMed PMID: 23773817; PubMed Central PMCID: PMC3715959.

  38. Huang Z, Newcomb CJ, Zhou Y, Lei YP, Bringas P Jr, Stupp SI, Snead ML. (2013) The role of bioactive nanofibers in enamel regeneration mediated through integrin signals acting upon C/EBPα and c-Jun. Biomaterials. 2013 Apr;34(13):3303-14. doi: 10.1016/j.biomaterials.2013.01.054. Epub 2013 Feb 9. PubMed PMID: 23398885; PubMed Central PMCID: PMC3600413.

  39. Gibson MP, Liu Q, Zhu Q, Lu Y, Jani P, Wang X, Liu Y, Paine ML, Snead ML, Feng JQ, Qin C. (2013) Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis. Eur J Oral Sci. 2013 Apr;121(2):76-85. doi: 10.1111/eos.12020. Epub 2013 Feb 7. PubMed PMID: 23489896; PubMed Central PMCID: PMC3602929.

  40. Yazici H, Fong H, Wilson B, Oren EE, Amos FA, Zhang H, Evans JS, Snead ML, Sarikaya M, Tamerler C. (2013) Biological response on a titanium implant-grade surface functionalized with modular peptides. Acta Biomater. 2013 Feb;9(2):5341-52. doi: 10.1016/j.actbio.2012.11.004. PubMed PMID: 23159566; PubMed Central PMCID: PMC4410049.

  41. Chavez MG, Yu W, Biehs B, Harada H, Snead ML, Lee JS, Desai TA, Klein OD. (2013) Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms. Tissue Eng Part C Methods. 2013 Jan;19(1):15-24. doi: 10.1089/ten.TEC.2012.0232. Epub 2012 Aug 16. PubMed PMID: 22742471; PubMed Central PMCID: PMC3522131.

  42. Lacruz RS, Hacia JG, Bromage TG, Boyde A, Lei Y, Xu Y, Miller JD, Paine ML, Snead ML. (2012) The circadian clock modulates enamel development. J Biol Rhythms. 2012 Jun;27(3):237-45. doi: 10.1177/0748730412442830. PubMed PMID: 22653892; PubMed Central PMCID: PMC3511783.

  43. Gungormus M, Oren EE, Horst JA, Fong H, Hnilova M, Somerman MJ, Snead ML, Samudrala R, Tamerler C, Sarikaya M. (2012) Cementomimetics-constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides. Int J Oral Sci. 2012 Jun;4(2):69-77. doi: 10.1038/ijos.2012.40. PubMed PMID: 22743342; PubMed Central PMCID: PMC3412665.

  44. Newcomb CJ, Bitton R, Velichko YS, Snead ML, Stupp SI. (2012) The role of nanoscale architecture in supramolecular templating of biomimetic hydroxyapatite mineralization. Small. 2012 Jul 23;8(14):2195-202, 2194. doi: 10.1002/smll.201102150. Epub 2012 May 8. PubMed PMID: 22570174; PubMed Central PMCID: PMC3400347.

  45. Lacruz RS, Nakayama Y, Holcroft J, Nguyen V, Somogyi-Ganss E, Snead ML, White SN, Paine ML, Ganss B. (2012) Targeted overexpression of amelotin disrupts the microstructure of dental enamel. PLoS One. 2012;7(4):e35200. Epub 2012 Apr 23.PubMed PMID: 22539960; PubMed Central PMCID: PMC3335167.

  46. Lacruz RS, Smith CE, Bringas Jr P, Chen YB, Smith SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine ML. (2012) Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol. 2012 May;227(5):2264-75. doi: 10.1002/jcp.22965. PubMed PMID: 21809343; PubMed Central PMCID: PMC3243804.

  47. Tamburstuen MV, Snead ML, Reseland JE, Paine ML, Lyngstadaas SP. (2011) Ameloblastin upstream region contains structural elements regulating transcriptional activity in a stromal cell line derived from bone marrow. Eur J Oral Sci. 2011 Dec;119 Suppl 1:286-92. doi: 10.1111/j.1600-0722.2011.00910.x. PubMed PMID: 22243258; PubMed Central PMCID: PMC3370392.

  48. Huang Z, Kim J, Lacruz RS, Bringas P Jr, Glogauer M, Bromage TG, Kaartinen VM, Snead ML. (2011) Epithelial-specific knockout of the Rac1 gene leads to enamel defects. Eur J Oral Sci. 2011 Dec;119 Suppl 1:168-76. doi: 10.1111/j.1600-0722.2011.00904.x. PubMed PMID: 22243243.

  49. Kémoun P, Gronthos S, Snead ML, Rue J, Courtois B, Vaysse F, Salles JP, Brunel G. (2011) The role of cell surface markers and enamel matrix derivatives on human periodontal ligament mesenchymal progenitor responses in vitro. Biomaterials. 2011 Oct;32(30):7375-88. doi: 10.1016/j.biomaterials.2011.06.043. Epub 2011 Jul 23. PubMed PMID: 21784516.

  50. Wen X, Cawthorn WP, Macdougald OA, Stupp SI, Snead ML, Zhou Y. (2011) The influence of Leucine-rich amelogenin peptide on MSC fate by inducing Wnt10b expression. Biomaterials. 2011 Sep;32(27):6478-86. Epub 2011 Jun 12. PubMed PMID: 21663957;PubMed Central PMCID: PMC3134126.

  51. Bromley KM, Lakshminarayanan R, Lei YP, Snead ML, Moradian-Oldak J. (2011) Folding, Assembly, and Aggregation of Recombinant Murine Amelogenins with T21I and P41T Point Mutations. Cells Tissues Organs. 2011;194(2-4):284-90. Epub 2011 May 2.PubMed PMID: 21540557; PubMed Central PMCID: PMC3178092.

  52. Lacruz RS, Lakshminarayanan R, Bromley KM, Hacia JG, Bromage TG, Snead ML, Moradian-Oldak J, Paine ML. (2011) Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin. PLoS One. 2011 Mar 18;6(3):e18028. PubMed PMID: 21437261; PubMed Central PMCID: PMC3060920.

  53. Snead ML, Zhu DH, Lei Y, Luo W, Bringas PO Jr, Sucov HM, Rauth RJ, Paine ML, White SN. (2011) A simplified genetic design for mammalian enamel. Biomaterials. 2011 Apr;32(12):3151-7. Epub 2011 Feb 5. PubMed PMID: 21295848; PubMed Central PMCID: PMC3045652.

  54. Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD. (2011) PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci. 2011 Mar 1;124(Pt 5):745-54. Epub 2011 Feb 1. PubMed PMID: 21285247; PubMed Central PMCID: PMC3039019.

  55. Riksen EA, Kalvik A, Brookes S, Hynne A, Snead ML, Lyngstadaas SP, Reseland JE. (2011) Fluoride reduces the expression of enamel proteins and cytokines in an ameloblast-derived cell line. Arch Oral Biol. 2011 Apr;56(4):324-30. doi:10.1016/j.archoralbio.2010.10.024. Epub 2010 Dec 17. PubMed PMID: 21167474.

  56. Tamburstuen MV, Reseland JE, Spahr A, Brookes SJ, Kvalheim G, Slaby I, Snead ML, Lyngstadaas SP. (2011) Ameloblastin expression and putative autoregulation in mesenchymal cells suggest a role in early bone formation and repair. Bone. 2011 Feb 1;48(2):406-13. Epub 2010 Sep 18. PubMed PMID: 20854943.

  57. Laksminarayanan R, Bromley KM, Lei YP, Snead ML, Moradian-Oldak J. (2010) Perturbed amelogenin secondary structure leads to uncontrolled aggregation in amelogenesis imperfecta mutant proteins. J Biol Chem. 2010 Dec 24;285(52):40593-603. Epub 2010 Oct 7. PubMed PMID: 20929860; PubMed Central PMCID: PMC3003358.

  58. Riksen EA, Stunes AK, Kalvik A, Gustafsson BI, Snead ML, Syversen U, Lyngstadaas SP, Reseland JE. (2010) Serotonin and fluoxetine receptors are expressed in enamel organs and LS8 cells and modulate gene expression in LS8 cells. Eur J Oral Sci. 2010 Dec;118(6):566-73. doi: 10.1111/j.1600-0722.2010.00778.x. Epub 2010 Sep 30. PubMed PMID: 21083617.

  59. Huang Z, Newcomb CJ, Bringas P Jr, Stupp SI, Snead ML. (2010) Biological synthesis of tooth enamel instructed by an artificial matrix. Biomaterials. 2010 Dec;31(35):9202-11. Epub 2010 Sep 24. PubMed PMID: 20869764; PubMed Central PMCID: PMC2956865.

  60. Zhang H, Tompkins K, Garrigues J, Snead ML, Gibson CW, Somerman MJ. (2010) Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells. Arch Oral Biol. 2010 Jun;55(6):417-25. Epub 2010 Apr 10. PubMed PMID: 20382373; PubMed Central PMCID: PMC2886511.

  61. Buchko GW, Tarasevich BJ, Roberts J, Snead ML, Shaw WJ. (2010) A solution NMR investigation into the murine amelogenin splice-variant LRAP (Leucine-Rich Amelogenin Protein). Biochim Biophys Acta. 2010 Sep;1804(9):1768-74. doi:10.1016/j.bbapap.2010.03.006. Epub 2010 Mar 19. PubMed PMID: 20304108; PubMed Central PMCID: PMC2910175.

  62. Rauth RJ, Potter KS, Ngan AY, Saad DM, Mehr R, Luong VQ, Schuetter VL, Miklus VG, Chang P, Paine ML, Lacruz RS, Snead ML, White SN. (2009) Dental enamel: genes define biomechanics. J Calif Dent Assoc. 37(12):863-8. PubMed PMID:20066874; PubMed Central PMCID: PMC2825347.

  63. Snead ML, Slavkin HC. (2009) Science is the fuel for the engine of technology and clinical practice. J Am Dent Assoc. 140 Suppl 1:17S-24S. PubMed PMID:19723927.

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  66. Huang Z, Sargeant T, Hulvat J, Mata A, Bringas P, Koh CY, Stupp S, Snead M. (2008) Bioactive Nanofibers Instruct Cells to Proliferate and Differentiate During Enamel Regeneration. J Bone Miner Res. 23(12):1995-2006. PubMed PMID: 18665793; PubMed Central PMCID: PMC2686923.

  67. Paine ML, Snead ML, Wang HJ, Abuladze N, Pushkin A, Liu W, Kao LY, Wall SM, Kim YH, Kurtz I. (2008) Role of NBCe1 and AE2 in secretory ameloblasts. J Dent Res. 87(4):391-5. PubMed PMID: 18362326; PubMed Central PMCID: PMC2504252.

  68. Wen X, Zou Y, Luo W, Goldberg M, Moats R, Conti PS, Snead ML, Paine ML. (2008) Biglycan Overexpression on Tooth Enamel Formation in Transgenic Mice. Anat Rec (Hoboken). 291(10):1246-53. PubMed PMID: 18727043; PubMed Central PMCID: PMC2562349.

  69. Snead ML. (2008) Whole-tooth regeneration: it takes a village of scientists, clinicians, and patients. J Dent Educ. 72(8):903-11. PubMed PMID: 18676799; PubMed Central PMCID: PMC2546443.

  70. Zhou Y, Snead ML. (2008) Derivation of cranial neural crest-like cells from human embryonic stem cells. Biochem Biophys Res Commun. 376(3):542-7. PubMed PMID: 18804450; PubMed Central PMCID: PMC2574922.

  71. Warotayanont R, Zhu D, Snead ML, Zhou Y. (2008) Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells. Biochem Biophys Res Commun. 367(1):1-6. PubMed PMID: 18086559; PubMed Central PMCID: PMC2276612.

  72. Buchko GW, Bekhazi J, Cort JR, Valentine NB, Snead ML, Shaw WJ. (2008) 1H, 13C, and 15N resonance assignments of murine amelogenin, an enamel biomineralization protein. Biomol NMR Assign. 2008 Jun;2(1):89-91. doi: 10.1007/s12104-008-9092-x. PubMed PMID: 19081741; PubMed Central PMCID: PMC2600544.

  73. Buchko GW, Tarasevich BJ, Bekhazi J, Snead ML, Shaw WJ. (2008) A solution NMR investigation into the early events of amelogenin nanosphere self-assembly initiated with sodium chloride or calcium chloride. Biochemistry. 2008 Dec 16;47(50):13215-22. PubMed PMID: 19086270; PubMed Central PMCID: PMC2663401.

  74. Tarasevich BJ, Howard CJ, Larson JL, Snead ML, Simmer JP, Paine M, Shaw WJ. (2007) The nucleation and growth of calcium phosphate by amelogenin. J Cryst Growth. 2007 Jun 15;304(2):407-415. PubMed PMID: 19079557; PubMed Central PMCID: PMC2597808.

  75. Mendoza G, Pemberton TJ, Lee K, Scarel-Caminaga R, Mehrian-Shai R, Gonzalez-Quevedo C, Ninis V, Hartiala J, Allayee H, Snead ML, Leal SM, Line SR, Patel PI. (2007) A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q24.3. Hum Genet. 2007 Jan;120(5):653-62. Epub 2006 Sep 21. PubMed PMID: 17024372.

  76. Zou Y, Wang H, Shapiro JL, Okamoto CT, Brookes SJ, Lyngstadaas SP, Snead ML, Paine ML. (2007) Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1. Biochem J. 2007 Dec 15;408(3):347-54. PubMed PMID: 17708745; PubMed Central PMCID: PMC2267358.

  77. Xu Y, Zhou YL, Erickson RL, Macdougald OA, Snead ML. (2007) Physical dissection of the CCAAT/enhancer-binding protein alpha in regulating the mouse amelogenin gene. Biochem Biophys Res Commun. 354(1):56-61. PubMed PMID: 17210130; PubMed Central PMCID: PMC1831826.

  78. Xu Y, Zhou YL, Gonzalez FJ, Snead ML. (2007) CCAAT/enhancer-binding protein delta (C/EBPdelta) maintains amelogenin expression in the absence of C/EBPalpha in vivo. J Biol Chem. 282(41):29882-9. PubMed PMID: 17704518.

  79. White SN, Paine ML, Ngan AY, Miklus VG, Luo W, Wang H, Snead ML. (2007) Ectopic expression of dentin sialoprotein during amelogenesis hardens bulk enamel. J Biol Chem. 282(8):5340-5. PubMed PMID: 17189271.

  80. Pemberton TJ, Li FY, Oka S, Mendoza-Fandino GA, Hsu YH, Bringas P Jr, Chai Y, Snead ML, Mehrian-Shai R, Patel PI. (2007) Identification of novel genes expressed during mouse tooth development by microarray gene expression analysis. Dev Dyn. 2007 Aug;236(8):2245-57. PubMed PMID: 17626284; PubMed Central PMCID: PMC4457363.

  81. Shapiro JL, Wen X, Okamoto CT, Wang HJ, Lyngstadaas SP, Goldberg M, Snead ML, Paine ML. (2007) Cellular uptake of amelogenin, and its localization to CD63, and Lamp1-positive vesicles. Cell Mol Life Sci. 64(2):244-56. PubMed PMID: 17187173.

  82. Xu Y, Zhou YL, Ann DK, MacDougald OA, Shum L, Snead ML. (2006) Transcription factor sumoylation and factor YY1 serve to modulate mouse amelogenin gene expression. Eur J Oral Sci. 2006 May;114 Suppl 1:169-77; discussion 201-2, 381. doi: 10.1111/j.1600-0722.2006.00319.x. PMID: 16674681.

  83. Xu Y, Zhou YL, Luo W, Zhu QS, Levy D, MacDougald OA, Snead ML. (2006) NF-Y and CCAAT/enhancer-binding protein alpha synergistically activate the mouse amelogenin gene. J Biol Chem. 2006 Jun 9;281(23):16090-8. doi: 10.1074/jbc.M510514200. Epub 2006 Apr 4. PMID: 16595692.

  84. Swanson EC, Fong HK, Foster BL, Paine ML, Gibson CW, Snead ML, Somerman MJ. (2006) Amelogenins regulate expression of genes associated with cementoblasts in vitro. Eur J Oral Sci. 114 Suppl 1:239-43; discussion 254-6, 381-2. PubMed PMID: 16674692.

  85. Wang HJ, Tannukit S, Wen X, Shapiro JL, Snead ML, Paine ML. (2006) Using the yeast two-hybrid assay to discover protein partners for the leucine-rich amelogenin peptide and for tuftelin-interacting protein 11. Eur J Oral Sci. 2006 May;114 Suppl 1:276-9; discussion 285-6, 382. doi: 10.1111/j.1600-0722.2006.00289.x. PMID: 16674698.

  86. Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen X, White SN, Zhou YL. 3. (2006) Protein-protein interactions of the developing enamel matrix. Curr Top Dev Biol. 2006;74:57-115. doi: 10.1016/S0070-2153(06)74003-0. PMID: 16860665.

  87. Bartold PM, Xiao Y, Lyngstaadas SP, Paine ML, Snead ML. (2006) Principles and applications of cell delivery systems for periodontal regeneration. Periodontol 2000. 2006;41:123-35. doi: 10.1111/j.1600-0757.2006.00156.x. PMID: 16686930.

  88. Zhu D, Paine ML, Luo W, Bringas P Jr, Snead ML. (2006) Altering biomineralization by protein design. J Biol Chem. 2006 Jul 28;281(30):21173-21182. doi: 10.1074/jbc.M510757200. Epub 2006 May 17. PMID: 16707492.

  89. Plikus MV, Zeichner-David M, Mayer JA, Reyna J, Bringas P, Thewissen JG, Snead ML, Chai Y, Chuong CM. (2005) Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. Evol Dev. 2005 Sep-Oct;7(5):440-57. doi: 10.1111/j.1525-142X.2005.05048.x. PMID: 16174037; PMCID: PMC4386657.

  90. Kubota K, Lee DH, Tsuchiya M, Young CS, Everett ET, Martinez-Mier EA, Snead ML, Nguyen L, Urano F, Bartlett JD. (2005) Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. J Biol Chem. 2005 Jun 17;280(24):23194-202. Epub 2005 Apr 23. PubMed PMID: 15849362.

  91. Paine ML, Snead ML. (2005) Tooth developmental biology: disruptions to enamel-matrix assembly and its impact on biomineralization. Orthod Craniofac Res. 2005 Nov;8(4):239-51. doi: 10.1111/j.1601-6343.2005.00346.x. PMID: 16238604.

  92. Paine ML, Luo W, Wang HJ, Bringas P Jr, Ngan AY, Miklus VG, Zhu DH, MacDougall M, White SN, Snead ML. (2005) Dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis. J Biol Chem. 2005 Sep 9;280(36):31991-8. doi: 10.1074/jbc.M502991200. Epub 2005 Jul 13. PMID: 16014627.

  93. Wang H, Tannukit S, Zhu D, Snead ML, Paine ML. (2005) Enamel matrix protein interactions. J Bone Miner Res. 2005 Jun;20(6):1032-40. doi: 10.1359/JBMR.050111. Epub 2005 Jan 24. PMID: 15883644.

  94. Wen X, Lei YP, Zhou YL, Okamoto CT, Snead ML, Paine ML. (2005) Structural organization and cellular localization of tuftelin-interacting protein 11 (TFIP11). Cell Mol Life Sci. 2005 May;62(9):1038-46. doi: 10.1007/s00018-005-4547-z. PMID: 15868102.

  95. White SN, Miklus VG, Chang PP, Caputo AA, Fong H, Sarikaya M, Luo W, Paine ML, Snead ML. (2005) Controlled failure mechanisms toughen the dentino-enamel junction zone. J Prosthet Dent. 2005 Oct;94(4):330-5. doi: 10.1016/j.prosdent.2005.08.013. PMID: 16198169.

  96. Shaw WJ, Campbell AA, Paine ML, Snead ML. (2004) The COOH terminus of the amelogenin, LRAP, is oriented next to the hydroxyapatite surface. J Biol Chem. 2004 Sep 24;279(39):40263-6. doi: 10.1074/jbc.C400322200. Epub 2004 Aug 5. PMID: 15299015.

  97. Paine ML, Zhu DH, Luo W, Snead ML. (2004) Overexpression of TRAP in the enamel matrix does not alter the enamel structural hierarchy. Cells Tissues Organs. 2004;176(1-3):7-16. doi: 10.1159/000075023. PMID: 14745231.

  98. Luo W, Wen X, Wang HJ, MacDougall M, Snead ML, Paine ML. (2004) In vivo overexpression of tuftelin in the enamel organic matrix. Cells Tissues Organs. 2004;177(4):212-20. doi: 10.1159/000080134. PMID: 15459477.

  99. Boabaid F, Gibson CW, Kuehl MA, Berry JE, Snead ML, Nociti FH Jr, Katchburian E, Somerman MJ. (2004) Leucine-rich amelogenin peptide: a candidate signaling molecule during cementogenesis. J Periodontol. 2004 Aug;75(8):1126-36. PubMed PMID: 15455742.

  100. Viswanathan HL, Berry JE, Foster BL, Gibson CW, Li Y, Kulkarni AB, Snead ML, Somerman MJ. (2003) Amelogenin: a potential regulator of cementum-associated genes. J Periodontol. 2003 Oct;74(10):1423-31. PubMed PMID: 14653387.

  101. Barrow SY, Xionan X, LeGeros AR, Mijares DQ, LeGeros RZ, Galvis DL, Snead M, Tavares M, Cruz GD. (2003) Dental caries prevalence among a sample of African American adults in New York City. Dent Clin North Am. 2003 Jan;47(1):57-65, viii-ix. PubMed PMID: 12519005.

  102. Paine ML, Luo W, Zhu DH, Bringas P Jr, Snead ML. (2003) Functional domains for amelogenin revealed by compound genetic defects. J Bone Miner Res. 2003 Mar;18(3):466-72. doi: 10.1359/jbmr.2003.18.3.466. PMID: 12619931.

  103. Paine ML, Wang HJ, Snead ML. (2003) Amelogenin self-assembly and the role of the proline located within the carboxyl-teleopeptide. Connect Tissue Res. 2003;44 Suppl 1:52-7. PMID: 12952174.

  104. Paine ML, Wang HJ, Luo W, Krebsbach PH, Snead ML. (2003) A transgenic animal model resembling amelogenesis imperfecta related to ameloblastin overexpression. J Biol Chem. 2003 May 23;278(21):19447-52. doi: 10.1074/jbc.M300445200. Epub 2003 Mar 25. PMID: 12657627.

  105. Fong H, White SN, Paine ML, Luo W, Snead ML, Sarikaya M. (2003) Enamel structure properties controlled by engineered proteins in transgenic mice. J Bone Miner Res. 2003 Nov;18(11):2052-9. doi: 10.1359/jbmr.2003.18.11.2052. PMID: 14606519.

  106. Snead ML. (2003) Amelogenin protein exhibits a modular design: implications for form and function. Connect Tissue Res. 2003;44 Suppl 1:47-51. PMID: 12952173.

  107. Wu LY, Li M, Hinton DR, Guo L, Jiang S, Wang JT, Zeng A, Xie JB, Snead M, Shuler C, Maxson RE Jr, Liu YH. (2003) Microphthalmia resulting from MSX2-induced apoptosis in the optic vesicle. Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2404-12. doi: 10.1167/iovs.02-0317. PMID: 12766037.

  108. Paine ML, Lei YP, Dickerson K, Snead ML. (2002) Altered amelogenin self-assembly based on mutations observed in human X-linked amelogenesis imperfecta (AIH1). J Biol Chem. 2002 May 10;277(19):17112-6. doi: 10.1074/jbc.M110473200. Epub 2002 Feb 27. PMID: 11877393.

  109. Dunglas C, Septier D, Paine ML, Zhu DH, Snead ML, Goldberg M. (2002) Ultrastructure of forming enamel in mouse bearing a transgene that disrupts the amelogenin self-assembly domains. Calcif Tissue Int. 2002 Aug;71(2):155-66. doi: 10.1007/s00223-001-2116-5. Epub 2002 Jun 20. PMID: 12073155.

  110. Jitpukdeebodintra S, Chai Y, Snead ML. (2002) Developmental patterning of the circumvallate papilla. Int J Dev Biol. 2002 Aug;46(5):755-63. PMID: 12216988.

  111. Paine ML, White SN, Luo W, Fong H, Sarikaya M, Snead ML. (2001) Regulated gene expression dictates enamel structure and tooth function. Matrix Biol. 2001 Sep;20(5-6):273-92. doi: 10.1016/s0945-053x(01)00153-6. PMID: 11566262.

  112. White SN, Luo W, Paine ML, Fong H, Sarikaya M, Snead ML. (2001) Biological organization of hydroxyapatite crystallites into a fibrous continuum toughens and controls anisotropy in human enamel. J Dent Res. 2001 Jan;80(1):321-6. doi: 10.1177/00220345010800010501. PMID: 11269723.

  113. Green PD, Hjalt TA, Kirk DE, Sutherland LB, Thomas BL, Sharpe PT, Snead ML, Murray JC, Russo AF, Amendt BA. (2001) Antagonistic regulation of Dlx2 expression by PITX2 and Msx2: implications for tooth development. Gene Expr. 2001;9(6):265-81. PubMed PMID: 11763998.

  114. Zhou YL, Lei Y, Snead ML. (2000) Functional antagonism between Msx2 and CCAAT/enhancer-binding protein alpha in regulating the mouse amelogenin gene expression is mediated by protein-protein interaction. J Biol Chem. 2000 Sep 15;275(37):29066-75. doi: 10.1074/jbc.M002031200. PMID: 10859305.

  115. Zhou YL, Snead ML. (2000) Identification of CCAAT/enhancer-binding protein alpha as a transactivator of the mouse amelogenin gene. J Biol Chem. 2000 Apr 21;275(16):12273-80. doi: 10.1074/jbc.275.16.12273. PMID: 10766866.

  116. Paine ML, Zhu DH, Luo W, Bringas P Jr, Goldberg M, White SN, Lei YP, Sarikaya M, Fong HK, Snead ML. (2000) Enamel biomineralization defects result from alterations to amelogenin self-assembly. J Struct Biol. 2000 Dec;132(3):191-200. doi: 10.1006/jsbi.2000.4324. Erratum in: J Struct Biol. 2005 Jul;151(1):116. PMID: 11243888.

  117. Moradian-Oldak J, Paine ML, Lei YP, Fincham AG, Snead ML. (2000) Self-assembly properties of recombinant engineered amelogenin proteins analyzed by dynamic light scattering and atomic force microscopy. J Struct Biol. 2000 Jul;131(1):27-37. doi: 10.1006/jsbi.2000.4237. PMID: 10945967.

  118. Paine CT, Paine ML, Luo W, Okamoto CT, Lyngstadaas SP, Snead ML. (2000) A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts. J Biol Chem. 2000 Jul 21;275(29):22284-92. doi: 10.1074/jbc.M000118200. PMID: 10806191.

  119. Dhamija S, Liu Y, Yamada Y, Snead ML, Krebsbach PH. (1999) Cloning and characterization of the murine ameloblastin promoter. J Biol Chem. 1999 Jul 16;274(29):20738-43. PubMed PMID: 10400709.

  120. Liu YH, Tang Z, Kundu RK, Wu L, Luo W, Zhu D, Sangiorgi F, Snead ML, Maxson RE. (1999) Msx2 gene dosage influences the number of proliferative osteogenic cells in growth centers of the developing murine skull: a possible mechanism for MSX2-mediated craniosynostosis in humans. Dev Biol. 1999 Jan 15;205(2):260-74. PubMed PMID: 9917362.

  121. Nanci A, Zalzal S, Lavoie P, Kunikata M, Chen W, Krebsbach PH, Yamada Y, Hammarström L, Simmer JP, Fincham AG, Snead ML, Smith CE. (1998) Comparative immunochemical analyses of the developmental expression and distribution of ameloblastin and amelogenin in rat incisors. J Histochem Cytochem. 1998 Aug;46(8):911-34. PubMed PMID: 9671442.

  122. Paine ML, Krebsbach PH, Chen LS, Paine CT, Yamada Y, Deutsch D, Snead ML. (1998) Protein-to-protein interactions: criteria defining the assembly of the enamel organic matrix. J Dent Res. 1998 Mar;77(3):496-502. PubMed PMID: 9496923.

  123. Paine CT, Paine ML, Snead ML. (1998) Identification of tuftelin- and amelogenin-interacting proteins using the yeast two-hybrid system. Connect Tissue Res. 1998;38(1-4):257-67;discussion 295-303. doi: 10.3109/03008209809017046. PMID: 11063033.

  124. Liu YH, Snead ML, Maxson RE Jr. (1998) Transgenic mouse models of craniofacial disorders. Methods Mol Biol. 2000;137:499-512. doi: 10.1385/1-59259-066-7:499. PMID: 10948563.

  125. Jaskoll T, Luo W, Snead ML. (1998) Msx-2 expression and glucocorticoid-induced overexpression in embryonic mouse submandibular glands. J Craniofac Genet Dev Biol. 1998 Apr-Jun;18(2):79-87. PMID: 9672840.

  126. Snead ML, Paine ML, Luo W, Zhu DH, Yoshida B, Lei YP, Paine CT, Chen LS, Burstein JM, Jitpukdeebudintra S, White SN, Bringas P Jr. (1998) Transgene animal model for protein expression and accumulation into forming enamel. Connect Tissue Res. 1998;38(1-4):279-86; discussion 295-303. doi: 10.3109/03008209809017048. PMID: 11063035.

  127. Fincham AG, Baehner R, Chai Y, Crowe DL, Fincham C, Iskander M, Landesman HM, Lee M, Luo W, Paine M, Pereira L, Moradian-Oldak J, Rosenblum A, Snead ML, Thompson P, Wuenschell C, Zeichner-David M, Shuler CF. (1997) Problem-based learning at the University of Southern California School of Dentistry. J Dent Educ. 1997 May;61(5):417-25. PMID: 9193445.

  128. Paine ML, Snead ML. (1997) Protein interactions during assembly of the enamel organic extracellular matrix. J Bone Miner Res. 1997 Feb;12(2):221-7. doi: 10.1359/jbmr.1997.12.2.221. PMID: 9041053.

  129. Snead ML. (1996) Enamel biology logodaedaly: getting to the root of the problem, or “who’s on first…”. J Bone Miner Res. 1996 Jul;11(7):899-904. doi: 10.1002/jbmr.5650110705. PMID: 8797109.

  130. Paine ML, Deutsch D, Snead ML. (1996) Carboxyl-region of tuftelin mediates self-assembly. Connect Tissue Res. 1996;35(1-4):157-61. doi: 10.3109/03008209609029187. PMID: 9084654.

  131. Liu YH, Ma L, Kundu R, Ignelzi M, Sangiorgi F, Wu L, Luo W, Snead ML, Maxson R. (1996) Function of the Msx2 gene in the morphogenesis of the skull. Ann N Y Acad Sci. 1996 Jun 8;785:48-58. doi: 10.1111/j.1749-6632.1996.tb56243.x. PMID: 8702183.

  132. Snead ML, Paine ML, Chen LS, Luo BY, Zhou DH, Lei YP, Liu YH, Maxson RE Jr. (1996) The murine amelogenin promoter: developmentally regulated expression in transgenic animals. Connect Tissue Res. 1996;35(1-4):41-7. doi: 10.3109/03008209609029173. PMID: 9084642.

  133. Liu YH, Kundu R, Wu L, Luo W, Ignelzi MA Jr, Snead ML, Maxson RE Jr. (1995) Premature suture closure and ectopic cranial bone in mice expressing Msx2 transgenes in the developing skull. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6137-41. doi: 10.1073/pnas.92.13.6137. PMID: 7597092; PMCID: PMC41657.

  134. Zeichner-David M, Diekwisch T, Fincham A, Lau E, MacDougall M, Moradian-Oldak J, Simmer J, Snead M, Slavkin HC. (1995) Control of ameloblast differentiation. Int J Dev Biol. 1995 Feb;39(1):69-92. PMID: 7626423.

  135. MacDougall M, Thiemann F, Ta H, Hsu P, Chen LS, Snead ML. (1995) Temperature sensitive simian virus 40 large T antigen immortalization of murine odontoblast cell cultures: establishment of clonal odontoblast cell line. Connect Tissue Res. 1995;33(1-3):97-103. doi: 10.3109/03008209509016988. PMID: 7554969.

  136. Ignelzi MA Jr, Liu YH, Maxson RE Jr, Snead ML. (1995) Genetically engineered mice: tools to understand craniofacial development. Crit Rev Oral Biol Med. 1995;6(3):181-201. doi: 10.1177/10454411950060030201. PMID: 8785260.

  137. Couwenhoven RI, Snead ML. (1994) Early determination and permissive expression of amelogenin transcription during mouse mandibular first molar development. Dev Biol. 1994 Jul;164(1):290-9. PubMed PMID: 8026631.

  138. Simmer JP, Lau EC, Hu CC, Aoba T, Lacey M, Nelson D, Zeichner-David M, Snead ML, Slavkin HC, Fincham AG. (1994) Isolation and characterization of a mouse amelogenin expressed in Escherichia coli. Calcif Tissue Int. 1994 Apr;54(4):312-9. PubMed PMID: 8062146.

  139. Tong HS, Sakai DD, Sims SM, Dixon SJ, Yamin M, Goldring SR, Snead ML, Minkin C. (1994) Murine osteoclasts and spleen cell polykaryons are distinguished by mRNA phenotyping. J Bone Miner Res. 1994 Apr;9(4):577-84. PubMed PMID: 8030446.

  140. Liu YH, Ma L, Wu LY, Luo W, Kundu R, Sangiorgi F, Snead ML, Maxson R. (1994) Regulation of the Msx2 homeobox gene during mouse embryogenesis: a transgene with 439 bp of 5′ flanking sequence is expressed exclusively in the apical ectodermal ridge of the developing limb. Mech Dev. 1994 Dec;48(3):187-97. doi: 10.1016/0925-4773(94)90059-0. PMID: 7893602.

  141. Jabs EW, Müller U, Li X, Ma L, Luo W, Haworth IS, Klisak I, Sparkes R, Warman ML, Mulliken JB, Snead ML, Maxson R. (1993) A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell. 1993 Nov 5;75(3):443-50. doi: 10.1016/0092-8674(93)90379-5. PMID: 8106171.

  142. Bell JR, Noveen A, Liu YH, Ma L, Dobias S, Kundu R, Luo W, Xia Y, Lusis AJ, Snead ML, et al. (1993) Genomic structure, chromosomal location, and evolution of the mouse Hox 8 gene. Genomics. 1993 Sep;17(3):800. doi: 10.1006/geno.1993.1417. Erratum for: Genomics. 1993 Apr;16(1):123-31. doi: 10.1006/geno.1993.1149. PMID: 7902329.

  143. Shum L, Sakakura Y, Bringas P Jr, Luo W, Snead ML, Mayo M, Crohin C, Millar S, Werb Z, Buckley S, et al. (1993) EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel’s cartilage during embryonic mouse mandibular morphogenesis in vitro. Development. 1993 Jul;118(3):903-17. doi: 10.1242/dev.118.3.903. PMID: 8076525.

  144. Couwenhoven RI, Schwartz SA, Snead ML. (1993) Arrest of amelogenin transcriptional activation in bromodeoxyuridine-treated developing mouse molars in vitro. J Craniofac Genet Dev Biol. 1993 Oct-Dec;13(4):259-69. PubMed PMID: 8288733.

  145. Gollard RP, Slavkin HC, Snead ML. (1992) Polyoma virus-induced murine odontogenic tumors. Oral Surg Oral Med Oral Pathol. 1992 Dec;74(6):761-7. doi: 10.1016/0030-4220(92)90405-f. PMID: 1336839.

  146. Lau EC, Simmer JP, Bringas P Jr, Hsu DD, Hu CC, Zeichner-David M, Thiemann F, Snead ML, Slavkin HC, Fincham AG. (1992) Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity. Biochem Biophys Res Commun. 1992 Nov 16;188(3):1253-60. PubMed PMID: 1445358.

  147. Watson JM, Spencer JA, Graves JA, Snead ML, Lau EC. (1992) Autosomal localization of the amelogenin gene in monotremes and marsupials: implications for mammalian sex chromosome evolution. Genomics. 1992 Nov;14(3):785-9. doi: 10.1016/s0888-7543(05)80187-9. PMID: 1427909.

  148. Jepsen S, Schiltz P, Strong DD, Scharla SH, Snead ML, Finkelman RD. (1992) Transforming growth factor-beta 1 mRNA in neonatal ovine molars visualized by in situ hybridization: potential role for the stratum intermedium. Arch Oral Biol. 1992 Aug;37(8):645-53. doi: 10.1016/0003-9969(92)90127-t. PMID: 1514937.

  149. Raaberg L, Nexø E, Buckley S, Luo W, Snead ML, Warburton D. (1992) Epidermal growth factor transcription, translation, and signal transduction by rat type II pneumocytes in culture. Am J Respir Cell Mol Biol. 1992 Jan;6(1):44-9. doi: 10.1165/ajrcmb/6.1.44. PMID: 1728293.

  150. Snead ML, Luo W, Hsu DD, Melrose RJ, Lau EC, Stenman G. (1992) Human ameloblastoma tumors express the amelogenin gene. Oral Surg Oral Med Oral Pathol. 1992 Jul;74(1):64-72. doi: 10.1016/0030-4220(92)90217-e. PMID: 1508512.

  151. Chen LS, Couwenhoven RI, Hsu D, Luo W, Snead ML. (1992) Maintenance of amelogenin gene expression by transformed epithelial cells of mouse enamel organ. Arch Oral Biol. 1992 Oct;37(10):771-8. doi: 10.1016/0003-9969(92)90110-t. PMID: 1444889.

  152. Kidd VJ, Luo W, Xiang JL, Tu F, Easton J, McCune S, Snead ML. (1991) Regulated expression of a cell division control-related protein kinase during development. Cell Growth Differ. 1991 Feb;2(2):85-93. PMID: 2069872.

  153. Chapman VM, Keitz BT, Disteche CM, Lau EC, Snead ML. (1991) Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome. Genomics. 1991 May;10(1):23-8. PubMed PMID: 1675194.

  154. Fincham AG, Bessem CC, Lau EC, Pavlova Z, Shuler C, Slavkin HC, Snead ML. (1991) Human developing enamel proteins exhibit a sex-linked dimorphism. Calcif Tissue Int. 1991 Apr;48(4):288-90. PubMed PMID: 2059881.

  155. Fincham AG, Hu Y, Lau EC, Slavkin HC, Snead ML. (1991) Amelogenin post-secretory processing during biomineralization in the postnatal mouse molar tooth. Arch Oral Biol. 1991;36(4):305-17. doi: 10.1016/0003-9969(91)90101-y. PMID: 2064551.

  156. Luo W, Slavkin HC, Snead ML. (1991) Cells from Hertwig’s epithelial root sheath do not transcribe amelogenin. J Periodontal Res. 1991 Jan;26(1):42-7. doi: 10.1111/j.1600-0765.1991.tb01624.x. PMID: 1825333.

  157. Fincham AG, Hu YY, Lau E, Pavlova Z, Slavkin HC, Snead ML. (1990) Isolation and partial characterization of a human amelogenin from a single fetal dentition using HPLC techniques. Calcif Tissue Int. 1990 Aug;47(2):105-11. doi: 10.1007/BF02555993. PMID: 2390730.

  158. Lau EC, Slavkin HC, Snead ML. (1990) Analysis of human enamel genes: insights into genetic disorders of enamel. Cleft Palate J. 1990 Apr;27(2):121-30. doi: 10.1597/1545-1569(1990)027<0121:aohegi>2.3.co;2. PMID: 2187631.

  159. Couwenhoven RI, Luo W, Snead ML. (1990) Co-localization of EGF transcripts and peptides by combined immunohistochemistry and in situ hybridization. J Histochem Cytochem. 1990 Dec;38(12):1853-7. doi: 10.1177/38.12.2254649. PMID: 2254649.

  160. Slavkin HC, Sasano Y, Kikunaga S, Bessem C, Bringas P Jr, Mayo M, Luo W, Mak G, Rall L, Snead ML. (1990) Cartilage, bone and tooth induction during early embryonic mouse mandibular morphogenesis using serumless, chemically-defined medium. Connect Tissue Res. 1990;24(1):41-51. doi: 10.3109/03008209009152421. PMID: 2186890.

  161. Snead ML, Luo W, Oliver P, Nakamura M, Don-Wheeler G, Bessem C, Bell GI, Rall LB, Slavkin HC. (1989) Localization of epidermal growth factor precursor in tooth and lung during embryonic mouse development. Dev Biol. 1989 Aug;134(2):420-9. doi: 10.1016/0012-1606(89)90114-0. PMID: 2663575.

  162. Amar S, Luo W, Snead ML, Ruch JV. (1989) Amelogenin gene expression in mouse incisor heterotopic recombinations. Differentiation. 1989 Jul;41(1):56-61. doi: 10.1111/j.1432-0436.1989.tb00732.x. PMID: 2806773.

  163. Couwenhoven RI, Davis C, Snead ML. (1989) Mouse ameloblasts do not transcribe the albumin gene. Calcif Tissue Int. 1989 Dec;45(6):367-71. doi: 10.1007/BF02556008. PMID: 2509028.

  164. Snead ML. (1989) Developmental biology and pathobiology: fusion through molecular biology. J Dent Res. 1989 Dec;68(12):1790-1. doi: 10.1177/00220345890680121401. PMID: 2600263.

  165. Fincham AG, Hu YY, Pavlova Z, Slavkin HC, Snead ML. (1989) Human amelogenins: sequences of “TRAP” molecules. Calcif Tissue Int. 1989 Oct;45(4):243-50. doi: 10.1007/BF02556044. PMID: 2509010.

  166. Fincham AG, Bessem CC, Bringas P Jr, Hu YY, Snead ML, Slavkin HC. (1989) Amelogenesis in vitro: a model for studies of epithelial postsecretory processing during tissue-specific extracellular matrix biomineralization. Differentiation. 1989 Jul;41(1):62-71. doi: 10.1111/j.1432-0436.1989.tb00733.x. PMID: 2806774.

  167. Slavkin HC, Bessem C, Fincham AG, Bringas P Jr, Santos V, Snead ML, Zeichner-David M. (1989) Human and mouse cementum proteins immunologically related to enamel proteins. Biochim Biophys Acta. 1989 Apr 25;991(1):12-8. doi: 10.1016/0304-4165(89)90021-4. PMID: 2469482.

  168. Lau EC, Mohandas TK, Shapiro LJ, Slavkin HC, Snead ML. (1989) Human and mouse amelogenin gene loci are on the sex chromosomes. Genomics. 1989 Feb;4(2):162-8. doi: 10.1016/0888-7543(89)90295-4. PMID: 2737677.

  169. Snead ML, Lau EC, Fincham AG, Zeichner-David M, Davis C, Slavkin HC. (1989) Of mice and men: anatomy of the amelogenin gene. Connect Tissue Res. 1989;22(1-4):101-9. Review. PubMed PMID: 2689082.

  170. Zeichner-David M, MacDougall M, Davis A, Vides J, Snead M, Slavkin H. (1989) Enamelins and amelogenins share the same amino-terminal sequence. Connect Tissue Res. 1989;22(1-4):123-9. PubMed PMID: 2598663.

  171. Slavkin HC, Bringas P Jr, Bessem C, Santos V, Nakamura M, Hsu MY, Snead ML, Zeichner-David M, Fincham AG. (1989) Hertwig’s epithelial root sheath differentiation and initial cementum and bone formation during long-term organ culture of mouse mandibular first molars using serumless, chemically-defined medium. J Periodontal Res. 1989 Jan;24(1):28-40. doi: 10.1111/j.1600-0765.1989.tb00854.x. PMID: 2524567.

  172. Zeichner-David M, Vides J, MacDougall M, Fincham A, Snead ML, Bessem C, Slavkin HC. (1988) Biosynthesis and characterization of rabbit tooth enamel extracellular-matrix proteins. Biochem J. 1988 May 1;251(3):631-41. PubMed PMID: 3415637; PubMed Central PMCID: PMC1149053.

  173. Slavkin HC, MacDougall M, Zeichner-David M, Oliver P, Nakamura M, Snead ML. (1988) Molecular determinants of cranial neural crest-derived odontogenic ectomesenchyme during dentinogenesis. Am J Med Genet Suppl. 1988;4:7-22. doi: 10.1002/ajmg.1320310508. PMID: 3144987.

  174. Slavkin HC, Bessem C, Bringas P Jr, Zeichner-David M, Nanci A, Snead ML. (1988) Sequential expression and differential function of multiple enamel proteins during fetal, neonatal, and early postnatal stages of mouse molar organogenesis. Differentiation. 1988;37(1):26-39. doi: 10.1111/j.1432-0436.1988.tb00793.x. PMID: 3384224.

  175. Luo W, Lau EC, Mostofi R, Roop D, Slavkin HC, Snead ML (1988) Gene expression in human ameloblastoma. J. Dent. Res. (special issue) 67:265.

  176. Luo W, Roop DR, Lau EC, Melrose RJ, Mostofi R, Stenman G, Snead ML. (1988) In situ hybridization analysis of keratin gene expression in human ameloblastomas. J Oral Pathol. 1988 Nov;17(9-10):534-40. doi: 10.1111/j.1600-0714.1988.tb01330.x. PMID: 2470885.

  177. Snead ML, Luo W, Rall LB, Bell GI, Slavkin HC (1988) Localization of PreProEGF messenger RNA in developing mouse molars using oligodeoxynucleotide probes. J. Dent. Res. 67:1830. Abstract.

  178. Snead ML, Luo W, Lau EC, Slavkin HC. (1988) Spatial- and temporal-restricted pattern for amelogenin gene expression during mouse molar tooth organogenesis. Development. 1988 Sep;104(1):77-85. doi: 10.1242/dev.104.1.77. PMID: 3253061.

  179. Slavkin HC, Snead ML, Zeichner-David M, MacDougall M, Fincham A, Lau EC, Luo W, Nakamura M, Oliver P, Evans J. (1988) Factors influencing the expression of dental extracellular matrix biomineralization. Ciba Found Symp. 1988;136:22-41. doi: 10.1002/9780470513637.ch3. PMID: 3068011.

  180. Luo W, Kidd V, Humphreys-Beher M, Slavkin HC, Snead ML (1987) Expression of 4 beta galactosyltransferase mRNA in ectoderm-dervied cells of the developing mouse submandibular gland. J. Cell Biology. 105:49a. Abstract.

  181. Snead ML, Lau EC. (1987) Examining the possible molecular origins for enamel protein complexity. Adv Dent Res. 1987 Dec;1(2):298-305. PubMed PMID: 3504180.

  182. Lau EC, Bessem CC, Slavkin HC, Zeichner-David M, Snead ML. (1987) Amelogenin antigenic domain defined by clonal epitope selection. Calcif Tissue Int. 1987 Apr;40(4):231-7. doi: 10.1007/BF02556627. PMID: 2438020.

  183. Zeichner-David M, MacDougall M, Vides J, Snead ML, Slavkin HC, Turkel SB, Pavlova Z. (1987) Immunochemical and biochemical studies of human enamel proteins during neonatal development. J Dent Res. 1987 Jan;66(1):50-6. doi: 10.1177/00220345870660011101. PMID: 2442216.

  184. Snead ML, Lau EC, Zeichner-David M, Fincham AG, Woo SL, Slavkin HC. (1985) DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein. Biochem Biophys Res Commun. 1985 Jun 28;129(3):812-8. doi: 10.1016/0006-291x(85)91964-3. PMID: 4015654.

  185. Snead ML, Bringas P Jr, Bessem C, Slavkin HC. (1984) De novo gene expression detected by amelogenin gene transcript analysis. Dev Biol. 1984 Jul;104(1):255-8. doi: 10.1016/0012-1606(84)90053-8. PMID: 6734939.

  186. Slavkin HC, Snead ML, Zeichner-David M, Jaskoll TF, Smith BT. (1984) Concepts of epithelial-mesenchymal interactions during development: tooth and lung organogenesis. J Cell Biochem. 1984;26(2):117-25. doi: 10.1002/jcb.240260207. PMID: 6396310.

  187. Snead ML, Zeichner-David M, Chandra T, Robson KJ, Woo SL, Slavkin HC. (1983) Construction and identification of mouse amelogenin cDNA clones. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7254-8. doi: 10.1073/pnas.80.23.7254. PMID: 6139813; PMCID: PMC390033.

  188. Schwartz SA, Snead ML. (1982) Bromodeoxyuridine-DNA interactions associated with arrest of rat odontogenesis in vitro. Arch Oral Biol. 1982;27(1):9-12. doi: 10.1016/0003-9969(82)90170-4. PMID: 6951533.

  189. Snead ML, Schwartz SA. (1980) Effect of 5-bromodeoxyuridine on extracellular matrix during odontogenesis in vitro. Virchows Arch B Cell Pathol Incl Mol Pathol. 1980;33(1):35-46. doi: 10.1007/BF02899169. PMID: 6162269.