![De-chen Lin](https://ccmb.usc.edu/files/2022/03/lin_dechen.jpeg)
Assistant Professor
Herman Ostrow School of Dentistry of USC
Associate Director of Research for the USC Head and Neck Center
Keck School of Medicine of USC
2250 Alcazar St.
CSA 207D – HSC 9062
Los Angeles, CA 90089
Phone: (323) 442-1220
Fax: (323) 442-2981
dechenli@usc.edu
Lab website:
sites.usc.edu/linlab
Nanjing University, China
B.S., 2005
Biology
Chinese Academy of Medical Sciences, China
Ph.D., 2010
Cell Biology
- 2023 – present – Associate Director of Research for the USC Head and Neck Center, Keck School of Medicine, University of Southern California, Los Angeles, CA
- 2022 – present – Assistant Professor – Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA
- 2020 – 2021 – Adjunct Associate Professor – UCLA School of Medicine, Los Angeles, CA
- 2016 – 2021 – Assistant Professor – Cedars-Sinai Medical Center, Los Angeles, CA
- 2014 – 2015 – Project Scientist – Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA
- 2013 – 2014 – Post-doctoral Fellow – Cedars-Sinai Medical Center, CA
- 2011 – 2013 – Post-doctoral Fellow – Cancer Science Institute of Singapore, National University of Singapore, Singapore
- 2020 – Readers Choice: The best of Oncogene 2019 (Agency: Nature Publishing Group)
- 2019 – The Best of AACR Award: most-cited research article in Cancer Research 2018 (Agency: American Association for Cancer Research (AACR))
- 2018-2020 – Clinical and Translational Science Institute (CTSI) Core Voucher Award
- 2018-2020 – DeGregorio Foundation Award for Cancers of the Esophagus and Stomach (Agency: DeGregorio Family Foundation)
- 2017-2019 – Tower Foundation Career Development Award (Agency: Tower Cancer Research Foundation)
- 2015-2017 – Donna and Jesse Garber Awards for Cancer Research (Agency: Cedars-Sinai Medical Center)
- 2015-2017 – American Society of Hematology (ASH) Fellow Scholar Award (Agency: American Society of Hematology)
- 2015-2017 – MDS Young Investigator Award (Agency: THE MDS FOUNDATION)
- 2014 – Incorporated Scholar-in-Training Award, AACR-Aflac (Agency: American Association for Cancer Research (AACR))
Modeling Pathways of Early Growth Dysregulation at the GEJ – Grant #5 R01 DK135562
- Principal Investigator: Stephen J Meltzer, Ph.D. and Dechen Lin, Ph.D.
- Sponsor: National Institutes of Health
- Period: 05/01/2024 – 02/28/2029
- Goal: The application will test the hypothesis that dysregulated Platelet Activating Factor (PTAF) and free fatty-acid (FFA) metabolism, via a novel epigenetic crosstalk featuring aberrant HNF4A transcription factor activation, is involved in growth dysregulation and early neoplastic evolution in cardia columnar cells at the human gastroesophageal junction (GEJ-cardia).
Pharmacological and dietary inhibition of a novel metabolic-epigenetic crosstalk in head and neck cancer – Grant #5 R01 CA033648
- Principal Investigator: Dechen Lin, Ph.D.
- Sponsor: National Institutes of Health
- Period: 03/01/2024 – 01/31/2029
- Goal: Head neck squamous cell carcinoma (HNSCC) is common and aggressive cancer without effective therapy. In this proposal, we will: i) focus on the crosstalk between cancer metabolism and epigenetic regulation to study the primary forces transforming normal oral cells into HNSCC using advanced organoid technology and mouse models; ii) investigate the pharmacological and dietary inhibition of the link between methionine metabolism and epigenetic network.
Development of genome-guided immunotherapeutic strategies for head neck cancer
- Principal Investigator: Dechen Lin, Ph.D.
- Sponsor: Ming Hsieh Institute Research Award
- Period: 08/01/2023 – 08/31/2024
- Goal: The major goal of this project is to develop MLL3 mutations as biomarkers to predict immunotherapeutic response in patients with head and neck squamous cancer using both animal models and patient-derived tumor organoids.
Master regulator transcription factors promote esophageal neoplastic evolution – Grant #5 R37 CA237022
- Principal Investigator: Dechen Lin, Ph.D.
- Sponsor: National Institutes of Health
- Period: 06/01/2020-05/31/2025
- Goal: To establish primary driving forces of BE-associated neoplasia evolution and uncover epigenomic mechanisms underlying esophagus transformation, which will fundamentally transform our insights into the biology of esophageal cancer.
Window pre-operative study of FID-007 in patients with squamous cell carcinoma of the head and neck
- Principal Investigator: Jacob Thomas MD; Co-Principal Investigator: Dechen Lin, Ph.D.
- Sponsor: Ming Hsieh Institute Research Award
- Period: 08/01/2023 – 08/31/2024
- Goal: The major goal of this project is to 1) conduct a clinical trial evaluating the combination of Taxane-based drugs and ICB therapies in HNSCC patients; 2) study the immune-modulating function of Taxane-based drugs using single-cell RNA-seq and patient-derived tumor organoids.
A central regulator and predictive biomarker for head neck cancer immunotherapy
- Principal Investigator: Uttum Sinha MD, Dechen Lin, Ph.D.
- Sponsor: The Wright Foundation
- Period: 08/01/2023 – 07/31/2024
- Goal: The major goal of this project is to perform single-cell RNA-seq analyses of HNSCC tumor microenvironment to understand the role on STAT1-IFN pathway in anti-tumor immune regulation and to develop biomarkers using multiplexed immunofluorescence of HNSCC tumor samples.
Vistoso Monreal A, Zhao H, Sedghizadeh PP, Lin DC*. Patient-derived tumor organoids to model drug response in gastric cancer. Cell Reports Medicine. July 16;5(7):101650. https://doi.org/10.1016/j.xcrm.2024.101650.
-
Nam C, Li LY, Yang Q, Ziman B, Zhao H, Hu B, Collet C, Jing P, Lei Q, Xu LY, Li EM, Koeffler HP, Sinha UK, Lin DC*. A druggable cascade links methionine metabolism to epigenomic reprogramming in squamous cell carcinoma. Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2320835121. doi: 10.1073/pnas.2320835121. Epub 2024 Jun 20. PMID: 38900797.
-
Ziman B, Yang Q, Zheng Y, Sheth M, Nam C, Zhao H, Zhang L, Hu B, Bhowmick NA, Sinha UK, Lin DC*. Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma. Cell Death Dis. 2024 Feb 19;15(2):152. PMID: 38373993.
-
Park, Y.M., Lin, DC. (2023) Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics. Nat Commun 14, 7017 (2023). https://doi.org/10.1038/s41467-023-42960-6.
-
Zheng, Y., Ziman, B., Ho, A. S., Sinha, U. K., Xu, L.-Y., Li, E.-M., Koeffler, H. P., Berman, B. P., & Lin, D.-C.. (2023) Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation. Genome Biology, 2023 Aug 24;24(1):193. doi: 10.1186/s13059-023-03035-3. PMID: 37620896.
-
Lin DC. Large-scale genomic analyses reveal alterations and mechanisms underlying clonal evolution and immune evasion in esophageal cancer. Nat Commun. Feb 17; (2023) 14:893. PMID: 36807265.
-
Sinha UK, Lin DC*. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics. 2023; 13(6):1823-1825. doi:10.7150/thno.83486.
-
Zhao H, Cheng Y, Kalra A, Ma K, Zheng Y, Ziman B, Tressler C, Glunde K, Shin EJ, Ngamruengphong S, Khashab M, Singh V, Anders RA, Jit S, Wyhs N, Chen W, Li X, Lin DC, Meltzer SJ. Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model. Sci Transl Med. 2022 Nov 30;14(673):eabq6146. doi: 10.1126/scitranslmed.abq6146. Epub 2022 Nov 30. PMID: 36449602.
-
Lin, DC*. Large-scale genomic analyses reveal alterations and mechanisms underlying clonal evolution and immune evasion in esophageal cancer. Nat Commun 14, 893 (2023). https://doi.org/10.1038/s41467-023-36557-2.
-
Uttam K. Sinha, W. Martin Kast, De-Chen Lin*. (2022) Single-cell genomics identifies immune response to neoadjuvant chemoradiotherapy. eBioMedicine, Volume 86. 2022, 104389, ISSN 2352-3964, https://doi.org/10.1016/j.ebiom.2022.104389.
-
Zhao H, Collet C, Peng D, Sinha UK, Lin DC. (2022) Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models. Computational and Structural Biotechnology Journal. https://doi.org/10.1016/j.csbj.2022.09.026.
-
Nam C, Ziman B, Sheth M, Zhao H, D-C. Lin. (2022) Genomic and Epigenomic Characterization of Tumor Organoid Models. Cancers. 2022, 14, 4090. https://doi.org/10.3390/cancers14174090.
-
Dinh H.Q, Pan F, Wang G, Q Huang, C Olingy, Z Wu, S Wang, X Xu, X Xu, J He, Q Yang, S Orsulic, M Haro, L Li, G Huang, J Breunig, H Koeffler, C Hedrick, L Xu, Lin DC, E Li. (2021) Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment. Nat Commun. 2021 Dec 17;12(1):7335. doi: 10.1038/s41467-021-27599-5. PMID: 34921160; PMCID: PMC8683407.
-
Ho AS, Robinson A, Shon W, Laury A, Raedschelders K, Venkatraman V, Holewinski R, Zhang Y, Shiao SL, Chen MM, Mallen-St Clair J, Lin DC, Zumsteg ZS, Van Eyk JE. (2021) Comparative Proteomic Analysis of HPV(+) Oropharyngeal Squamous Cell Carcinoma Recurrence. J Proteome Res. 2021 Nov 30. doi: 10.1021/acs.jproteome.1c00757. Epub ahead of print. PMID: 34846153.
-
Ho AS, Luu M, Shafqat I, Mallen-St Clair J, Chen MM, Chen Y, Jain M, Ali N, Patio C, Filarski CF, Lin DC, Bankston H, Braunstein GD, Sacks WL, Zumsteg ZS. (2021) Predictive Impact of Metastatic Lymph Node Burden on Distant Metastasis Across Papillary Thyroid Cancer Variants. Thyroid. 2021 Oct;31(10):1549-1557. doi:10.1089/thy.2021.0131. PMID: 34470466.
-
Lin DC. (2021) A closer look at esophageal cancer through different lenses. EBioMedicine. 2021 Sep;71:103545. doi: 10.1016/j.ebiom.2021.103545. Epub 2021 Aug 19. PMID: 34419929; PMCID: PMC8385164.
-
Li LY, Yang Q, Jiang YY, Yang W, Jiang Y, Li X, Hazawa M, Zhou B, Huang GW, Xu XE, Gery S, Zhang Y, Ding LW, Ho AS, Zumsteg ZS, Wang MR, Fullwood MJ, Freedland SJ, Meltzer SJ, Xu LY, Li EM, Koeffler HP, Lin DC. (2021) Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. Nat Commun. 2021 Jul 16;12(1):4362. doi: 10.1038/s41467-021-24656-x. PMID: 34272396; PMCID:PMC8285542.
-
Zheng Y, Huang G, Silva TC, Yang Q, Jiang YY, Koeffler HP, Lin DC, Berman BP. (2021) A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes. Nat Commun. 2021 Apr 30;12(1):2485. doi:10.1038/s41467-021-22720-0. Erratum in: Nat Commun. 2021 Jun 28;12(1):4106.PMID: 33931649; PMCID: PMC8087678.
-
Lin DC. (2021) Exercise impacts the epigenome of cancer. Prostate Cancer Prostatic Dis. 2021 May 27. doi: 10.1038/s41391-021-00396-3. Epub ahead of print. PMID: 34045658.
-
Jiang Y, Jiang YY, Lin DC. (2021) Super-enhancer-mediated core regulatory circuitry in human cancer. Comput Struct Biotechnol J. 2021 May 5;19:2790-2795. doi:10.1016/j.csbj.2021.05.006. PMID: 34093993; PMCID: PMC8138668.
-
Ho AS, Luu M, Kim S, Tighiouart M, Mita AC, Scher KS, Mallen-St Clair J, Walgama ES, Lin DC, Nguyen AT, Zumsteg ZS. (2021) Nodal staging convergence for HPV-and HPV+ oropharyngeal carcinoma. Cancer. 2021 May 15;127(10):1590-1597. doi:10.1002/cncr.33414. Epub 2021 Feb 17. PMID: 33595897.
-
Guo Z, Pan F, Peng L, Tian S, Jiao J, Liao L, Lu C, Zhai G, Wu Z, Dong H, Xu X, Wu J, Chen P, Bai X, Lin D, Xu L, Li E, Zhang K. (2021) Systematic Proteome and Lysine Succinylome Analysis Reveals the Enhanced Cell Migration by Hyposuccinylation in Esophageal Squamous Cell Cancer. Mol Cell Proteomics. 2021 Feb 6;20:100053. doi: 10.1074/mcp.RA120.002150. Epub ahead of print. PMID:33561546; PMCID: PMC7970140.
-
Ma S, Zhou B, Yang Q, Pan Y, Yang W, Freedland SJ, Ding LW, Freeman MR, Breunig JJ, Bhowmick NA, Pan J, Koeffler HP, Lin DC. (2021) A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma. Cancer Res. 2021 Mar 1;81(5):1216-1229. doi: 10.1158/0008-5472.CAN-20-0652. Epub 2021 Jan 5. PMID:33402390; PMCID: PMC8026506.
-
Shi X, Zheng Y, Jiang L, Zhou B, Yang W, Li L, Ding L, Huang M, Gery S, Lin DC, Koeffler HP. (2020) EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma. Nucleic Acids Res. 2020 Nov 18;48(20):11434-11451. doi: 10.1093/nar/gkaa901. PMID: 33080033; PMCID: PMC7672457.
-
Ho AS, Luu M, Barrios L, Balzer BL, Bose S, Fan X, Walgama E, Mallen-St Clair J, Alam U, Shafqat I, Lin DC, Chen Y, Van Eyk JE, Maghami EG, Braunstein GD, Sacks WL, Zumsteg ZS. (2020) Prognostic Impact of Histologic Grade for Papillary Thyroid Carcinoma. Ann Surg Oncol. 2021 Mar;28(3):1731-1739. doi:10.1245/s10434-020-09023-2. Epub 2020 Aug 17. PMID: 32808161.
-
Jiang YY, Jiang Y, Li CQ, Zhang Y, Dakle P, Kaur H, Deng JW, Lin RY, Han L, Xie JJ, Yan Y, Doan N, Zheng Y, Mayakonda A, Hazawa M, Xu L, Li Y, Aswad L, Jeitany M, Kanojia D, Guan XY, Said JW, Yang W, Fullwood MJ, Lin DC, Koeffler HP. (2020) TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines. Gastroenterology. 2020 Oct;159(4):1311-1327.e19. doi:10.1053/j.gastro.2020.06.050. Epub 2020 Jun 30. PMID: 32619460.
-
Wang QY, Peng L, Chen Y, Liao LD, Chen JX, Li M, Li YY, Qian FC, Zhang YX, Wang F, Li CQ, Lin DC, Xu LY, Li EM. (2020) Characterization of super-enhancer-associated functional lncRNAs acting as ceRNAs in ESCC. Mol Oncol. 2020 Sep;14(9):2203-2230. doi: 10.1002/1878-0261.12726. Epub 2020 Jun 20. PMID:32460441; PMCID: PMC7463357.
-
Pan J, Silva TC, Gull N, Yang Q, Plummer JT, Chen S, Daigo K, Hamakubo T, Gery S, Ding LW, Jiang YY, Hu S, Xu LY, Li EM, Ding Y, Klempner SJ, Gayther SA, Berman BP, Koeffler HP, Lin DC. (2020) Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas. Cancer Res. 2020 Jul 1;80(13):2722-2736. doi: 10.1158/0008-5472.CAN-20-0390. Epub 2020 Apr 24. PMID: 32332020.
-
Huang M, Wang Y, Yang M, Yan J, Yang H, Zhuang W, Xu Y, Koeffler HP, Lin DC, Chen X. (2020) dbInDel: a database of enhancer-associated insertion and deletion variants by analysis of H3K27ac ChIP-Seq. Bioinformatics. 2020 Mar 1;36(5):1649-1651. doi: 10.1093/bioinformatics/btz770. PMID: 31603498; PMCID:PMC7703781.
-
Chen Y, Liao LD, Wu ZY, Yang Q, Guo JC, He JZ, Wang SH, Xu XE, Wu JY, Pan F, Lin DC, Xu LY, Li EM. (2020) Identification of key genes by integrating DNA methylation and next-generation transcriptome sequencing for esophageal squamous cell carcinoma. Aging (Albany NY). 2020 Jan 21;12(2):1332-1365. doi:10.18632/aging.102686. Epub 2020 Jan 21. PMID: 31962291; PMCID: PMC7053602.
-
Liao JY, Yang B, Zhang YC, Wang XJ, Ye Y, Peng JW, Yang ZZ, He JH, Zhang Y, Hu K, Lin DC, Yin D. (2020) EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs). Nucleic Acids Res. 2020 Jan 8;48(D1):D307-D313. doi: 10.1093/nar/gkz823. PMID: 31598693; PMCID: PMC6943034.
-
Howard LE, Zhang J, Fishbane N, Hoedt AM, Klaassen Z, Spratt DE, Vidal AC, Lin D, Hitchins MP, You S, Freeman MR, Yamoah K, Davicioni E, Freedland SJ. (2020) Validation of a genomic classifier for prediction of metastasis and prostate cancer-specific mortality in African-American men following radical prostatectomy in an equal access healthcare setting. Prostate Cancer Prostatic Dis. 2020 Sep;23(3):419-428. doi: 10.1038/s41391-019-0197-3. Epub 2019 Dec 16. PMID: 31844180.
-
Hazawa M, Sakai K, Kobayashi A, Yoshino H, Iga Y, Iwashima Y, Lim KS, Chih-Cheng Voon D, Jiang YY, Horike SI, Lin DC, Wong RW. (2020) Disease-specific alteration of karyopherin-a subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma. Oncogene. 2020 Mar;39(10):2212-2223. doi:10.1038/s41388-019-1137-3. Epub 2019 Dec 10. PMID: 31822798; PMCID: PMC7056645.
-
Loh XY, Sun QY, Ding LW, Mayakonda A, Venkatachalam N, Yeo MS, Silva TC, Xiao JF, Doan NB, Said JW, Ran XB, Zhou SQ, Dakle P, Shyamsunder P, Koh AP, Huang RY, Berman BP, Tan SY, Yang H, Lin DC, Koeffler HP. (2020) RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling. Cancer Res. 2020 Jan 15;80(2):219-233. doi: 10.1158/0008-5472.CAN-18-2796. Epub 2019 Sep 24. PMID:31551365.
-
Chen L, Huang M, Plummer J, Pan J, Jiang YY, Yang Q, Silva TC, Gull N, Chen S, Ding LW, An O, Yang H, Cheng Y, Said JW, Doan N, Dinjens WN, Waters KM, Tuli R, Gayther SA, Klempner SJ, Berman BP, Meltzer SJ, Lin DC, Koeffler HP. (2020) Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma. Gut. 2020 Apr;69(4):630-640. doi: 10.1136/gutjnl-2019-318325. Epub 2019 Aug 13. PMID:31409603; PMCID: PMC8108390.
-
You R, Liu YP, Lin DC, Li Q, Yu T, Zou X, Lin M, Zhang XL, He GP, Yang Q, Zhang YN, Xie YL, Jiang R, Wu CY, Zhang C, Cui C, Wang JQ, Wang Y, Zhuang AH, Guo GF, Hua YJ, Sun R, Yun JP, Zuo ZX, Liu ZX, Zhu XF, Kang TB, Qian CN, Mai HQ, Sun Y, Zeng MS, Feng L, Zeng YX, Chen MY. (2019) Clonal Mutations Activate the NF-KB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma. Cancer Res. 2019 Dec 1;79(23):5930-5943. doi: 10.1158/0008-5472.CAN-18-3845. Epub 2019 Sep 4. PMID:31484669.
-
Lin L, Lin DC. (2019) Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma. Cancers (Basel). 2019 Aug 12;11(8):1156. doi: 10.3390/cancers11081156. PMID: 31409002; PMCID: PMC6721624.
-
Sun QY, Ding LW, Johnson K, Zhou S, Tyner JW, Yang H, Doan NB, Said JW, Xiao JF, Loh XY, Ran XB, Venkatachalam N, Lao Z, Chen Y, Xu L, Fan LF, Chien W, Lin DC, Koeffler HP. (2019) SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells. Oncogene. 2019 Aug;38(34):6196-6210. doi: 10.1038/s41388-019-0865-8. Epub 2019 Jul 22. PMID: 31332289.
-
Qian FC, Li XC, Guo JC, Zhao JM, Li YY, Tang ZD, Zhou LW, Zhang J, Bai XF, Jiang Y, Pan Q, Wang QY, Li EM, Li CQ, Xu LY, Lin DC. (2019) SEanalysis: a web tool for super-enhancer associated regulatory analysis. Nucleic Acids Res. 2019 Jul 2;47(W1):W248-W255. doi: 10.1093/nar/gkz302. PMID: 31028388; PMCID: PMC6602466.
-
Silva TC, Coetzee SG, Gull N, Yao L, Hazelett DJ, Noushmehr H, Lin DC, Berman BP. (2019) ELMER v.2: an R/Bioconductor package to reconstruct gene regulatory networks from DNA methylation and transcriptome profiles. Bioinformatics. 2019 Jun 1;35(11):1974-1977. doi: 10.1093/bioinformatics/bty902. PMID: 30364927; PMCID:PMC6546131.
-
Ding LW, Sun QY, Edwards JJ, Fernández LT, Ran XB, Zhou SQ, Scolyer RA, Wilmott JS, Thompson JF, Doan N, Said JW, Venkatachalam N, Xiao JF, Loh XY, Pein M, Xu L, Mullins DW, Yang H, Lin DC, Koeffler HP. (2019) LNK suppresses interferon signaling in melanoma. Nat Commun. 2019 May 20;10(1):2230. doi:10.1038/s41467-019-09711-y. PMID: 31110180; PMCID: PMC6527565.
-
Lin L, Huang M, Shi X, Mayakonda A, Hu K, Jiang YY, Guo X, Chen L, Pang B, Doan N, Said JW, Xie J, Gery S, Cheng X, Lin Z, Li J, Berman BP, Yin D, Lin DC, Koeffler HP. (2019) Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. Nucleic Acids Res. 2019 Feb 20;47(3):1255-1267. doi: 10.1093/nar/gky1207. PMID: 30496486; PMCID:PMC6379679.
-
Lao ZT, Ding LW, An O, Hattori N, Sun QY, Tan KT, Mayakonda A, Chuan WG, Madan V, Lin DC, Yang H, Koeffler HP. (2019) Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias. Haematologica. 2019 May;104(5):e200-e203. doi:10.3324/haematol.2018.202911. Epub 2018 Dec 4. PMID: 30514800; PMCID:PMC6518916.
-
Peng L, Jiang B, Yuan X, Qiu Y, Peng J, Huang Y, Zhang C, Zhang Y, Lin Z, Li J, Yao W, Deng W, Zhang Y, Meng M, Pan X, Li C, Yin D, Bi X, Li G, Lin DC. (2019) Super-Enhancer-Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma. Cancer Res. 2019 Feb 1;79(3):572-584. doi: 10.1158/0008-5472.CAN-18-0367. Epub 2018 Nov 27. PMID:30482773.
-
Ding LW, Tan KT, Sun QY, Lao ZT, Yang H, Jiang N, Chien W, Xiao JF, Loh XY, Huang ML, Lill M, Lin DC, Yeoh AEJ, Koeffler HP. (2019) Clonality and clonal evolution analysis of paediatric ALL based on B-cell receptor/T-cell receptor rearrangement. Br J Haematol. 2019 Mar;184(5):829-833. doi: 10.1111/bjh.15179. Epub 2018 Mar 13. PMID: 29532914.
-
Corces MR, Granja JM, Shams S, Louie BH, Seoane JA, Zhou W, Silva TC, Groeneveld C, Wong CK, Cho SW, Satpathy AT, Mumbach MR, Hoadley KA, Robertson AG, Sheffield NC, Felau I, Castro MAA, Berman BP, Staudt LM, Zenklusen JC, Laird PW, Curtis C; Cancer Genome Atlas Analysis Network, Greenleaf WJ, Chang HY. (2018) The chromatin accessibility landscape of primary human cancers. Science. 2018 Oct 26;362(6413):eaav1898. doi: 10.1126/science.aav1898. PMID: 30361341; PMCID:PMC6408149.
-
Mayakonda A, Lin DC, Assenov Y, Plass C, Koeffler HP. (2018) Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Res. 2018 Nov;28(11):1747-1756. doi: 10.1101/gr.239244.118. Epub 2018 Oct 19. PMID:30341162; PMCID: PMC6211645.
-
Tan KT, Ding LW, Sun QY, Lao ZT, Chien W, Ren X, Xiao JF, Loh XY, Xu L, Lill M, Mayakonda A, Lin DC, Yang H, Koeffler HP. (2018) Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines. BMC Cancer. 2018 Oct 1;18(1):940. doi: 10.1186/s12885-018-4840-5. PMID: 30285677; PMCID: PMC6167786.
-
Jiang Y, Jiang YY, Xie JJ, Mayakonda A, Hazawa M, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, Liao LD, Soukiasian HJ, Berman BP, Hao JJ, Xu LY, Li EM, Wang MR, Bi XG, Lin DC, Koeffler HP. (2018) Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nat Commun. 2018 Sep 6;9(1):3619. doi:10.1038/s41467-018-06081-9. PMID: 30190462; PMCID: PMC6127298.
-
Liu X, Cheng Y, Abraham JM, Wang Z, Wang Z, Ke X, Yan R, Shin EJ, Ngamruengphong S, Khashab MA, Zhang G, McNamara G, Ewald AJ, Lin D, Liu Z, Meltzer SJ. (2018) Modeling Wnt signaling by CRISPR-Cas9 genome editing recapitulates neoplasia in human Barrett epithelial organoids. Cancer Lett. 2018 Nov 1;436:109-118. doi: 10.1016/j.canlet.2018.08.017. Epub 2018 Aug 23. PMID:30144514; PMCID: PMC6152930.
-
Xiao JF, Sun QY, Ding LW, Chien W, Liu XY, Mayakonda A, Jiang YY, Loh XY, Ran XB, Doan NB, Castor B, Chia D, Said JW, Tan KT, Yang H, Fu XY, Lin DC, Koeffler HP. (2018) The c-MYC-BMI1 axis is essential for SETDB1-mediated breast tumourigenesis. J Pathol. 2018 Sep;246(1):89-102. doi: 10.1002/path.5126. Epub 2018 Aug 3. PMID:29926931.
-
Guo X, Zhang Y, Mayakonda A, Madan V, Ding LW, Lin LH, Zia S, Gery S, Tyner JW, Zhou W, Yin D, Lin DC, Koeffler HP. (2018) ARID1A and CEBPa cooperatively inhibit UCA1 transcription in breast cancer. Oncogene. 2018 Nov;37(45):5939-5951. doi:10.1038/s41388-018-0371-4. Epub 2018 Jul 6. PMID: 29980791.
-
Xie JJ, Jiang YY, Jiang Y, Li CQ, Lim MC, An O, Mayakonda A, Ding LW, Long L, Sun C, Lin LH, Chen L, Wu JY, Wu ZY, Cao Q, Fang WK, Yang W, Soukiasian H, Meltzer SJ, Yang H, Fullwood M, Xu LY, Li EM, Lin DC, Koeffler HP. (2018) Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma. Gastroenterology. 2018 Jun;154(8):2137-2151.e1. doi: 10.1053/j.gastro.2018.02.018. Epub 2018 Feb 15. Erratum in: Gastroenterology. 2021 Nov;161(5):1726-1727. PMID: 29454790.
-
Hazawa M, Lin DC, Kobayashi A, Jiang YY, Xu L, Dewi FRP, Mohamed MS, Hartono, Nakada M, Meguro-Horike M, Horike SI, Koeffler HP, Wong RW. (2018) ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation. EMBO Rep. 2018 Jan;19(1):73-88. doi: 10.15252/embr.201744523. Epub 2017 Dec 7. PMID: 29217659; PMCID: PMC5757218.
-
Zhao Z, Jia Q, Wu MS, Xie X, Wang Y, Song G, Zou CY, Tang Q, Lu J, Huang G, Wang J, Lin DC, Koeffler HP, Yin JQ, Shen J. (2018) Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3ß Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018 Jan 1;24(1):130-144. doi:10.1158/1078-0432.CCR-17-0692. Epub 2017 Sep 26. PMID: 28951519.
-
Takao S, Chien W, Madan V, Lin DC, Ding LW, Sun QY, Mayakonda A, Sudo M, Xu L, Chen Y, Jiang YY, Gery S, Lill M, Park E, Senapedis W, Baloglu E, Müschen M, Koeffler HP. (2018) Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia. Leukemia. 2018 Mar;32(3):616-625. doi: 10.1038/leu.2017.281. Epub 2017 Sep 14. PMID: 28904384.
-
Lin DC, Dinh HQ, Xie JJ, Mayakonda A, Silva TC, Jiang YY, Ding LW, He JZ, Xu XE, Hao JJ, Wang MR, Li C, Xu LY, Li EM, Berman BP, Phillip Koeffler H. (2018) Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas. Gut. 2018 Oct;67(10):1769-1779. doi: 10.1136/gutjnl-2017-314607. Epub 2017 Aug 31. PMID:28860350; PMCID: PMC5980794.
-
Lin DC, Wang MR, Koeffler HP. (2018) Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients. Gastroenterology. 2018 Jan;154(2):374-389. doi: 10.1053/j.gastro.2017.06.066. Epub 2017 Jul 27. PMID: 28757263; PMCID: PMC5951382.
-
Yu F, Lu Y, Tao L, Jiang YY, Lin DC, Wang L, Petersson F, Yoshiyama H, Koeffler PH, Goh BC, Loh KS. (2017) Non-malignant epithelial cells preferentially proliferate from nasopharyngeal carcinoma biopsy cultured under conditionally reprogrammed conditions. Sci Rep. 2017 Dec 12;7(1):17359. doi:10.1038/s41598-017-17628-z. PMID: 29234119; PMCID: PMC5727117.
-
Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin DC, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong LW, Cho H, Xie J, Li QZ, Müschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP. (2017) Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12548-12553. doi: 10.1073/pnas.1619119114. Epub 2017 Nov 6. PMID:29109286; PMCID: PMC5703267.
-
Lin DC, Koeffler HP. (2017) Genomic lesions drive the metastasis of esophageal squamous cell carcinoma. J Thorac Dis. 2017 Oct;9(10):3523-3524. doi:10.21037/jtd.2017.09.58. PMID: 29268331; PMCID: PMC5723768.
-
Yuan J, Jiang YY, Mayakonda A, Huang M, Ding LW, Lin H, Yu F, Lu Y, Loh TKS, Chow M, Savage S, Tyner JW, Lin DC, Koeffler HP. (2017) Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma. Cancer Res. 2017 Dec 1;77(23):6614-6626. doi: 10.1158/0008-5472.CAN-17-1143. Epub 2017 Sep 26. PMID:28951465; PMCID: PMC6637769.
-
Sun H, Lin DC, Guo X, Masouleh BK, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP. (2017) Correction: Inhibition of IRE1a-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget. 2017 Sep 8;8(38):64651. doi: 10.18632/oncotarget.20707. Erratum for: Oncotarget. 2016 Apr 5;7(14 ):18736-49. PMID: 28969101; PMCID: PMC5610033.
-
Gugliotta G, Sudo M, Cao Q, Lin DC, Sun H, Takao S, Le Moigne R, Rolfe M, Gery S, Müschen M, Cavo M, Koeffler HP. (2017) Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia. Neoplasia. 2017 Oct;19(10):750-761. doi: 10.1016/j.neo.2017.08.001. Epub 2017 Aug 29. PMID:28843399; PMCID: PMC5576979.
-
Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP. (2017) BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3981-3986. doi: 10.1073/pnas.1609758114. Epub 2017 Mar 29. Erratum in: Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4317. PMID: 28356518;PMCID: PMC5393201.
-
Sun H, Lin DC, Cao Q, Pang B, Gae DD, Lee VKM, Lim HJ, Doan N, Said JW, Gery S, Chow M, Mayakonda A, Forscher C, Tyner JW, Koeffler HP. (2017) Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma. Clin Cancer Res. 2017 Aug 1;23(15):4376-4387. doi:10.1158/1078-0432.CCR-16-2185. Epub 2017 Mar 23. PMID: 28336564.
-
Ding LW, Sun QY, Mayakonda A, Tan KT, Chien W, Lin DC, Jiang YY, Xu L, Garg M, Lao ZT, Lill M, Yang H, Yeoh AE, Koeffler HP. (2017) Mutational profiling of acute lymphoblastic leukemia with testicular relapse. J Hematol Oncol. 2017 Mar 2;10(1):65. doi: 10.1186/s13045-017-0434-y. PMID: 28253933; PMCID: PMC5335697.
-
Lin DC, Mayakonda A, Dinh HQ, Huang P, Lin L, Liu X, Ding LW, Wang J, Berman BP, Song EW, Yin D, Koeffler HP. (2017) Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma. Cancer Res. 2017 May 1;77(9):2255-2265. doi:10.1158/0008-5472.CAN-16-2822. Epub 2017 Feb 20. PMID: 28302680; PMCID:PMC5413372.
-
Li CQ, Huang GW, Wu ZY, Xu YJ, Li XC, Xue YJ, Zhu Y, Zhao JM, Li M, Zhang J, Wu JY, Lei F, Wang QY, Li S, Zheng CP, Ai B, Tang ZD, Feng CC, Liao LD, Wang SH, Shen JH, Liu YJ, Bai XF, He JZ, Cao HH, Wu BL, Wang MR, Lin DC, Koeffler HP, Wang LD, Li X, Li EM, Xu LY. (2017) Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. Oncogenesis. 2017 Feb 13;6(2):e297. doi: 10.1038/oncsis.2017.1. PMID: 28194033;PMCID: PMC5337622.
-
Xie J, Lin D, Lee DH, Akunowicz J, Hansen M, Miller C, Sanada M, Kato M, Akagi T, Kawamata N, Ogawa S, Koeffler HP. (2017) Copy number analysis identifies tumor suppressive lncRNAs in human osteosarcoma. Int J Oncol. 2017 Mar;50(3):863-872. doi: 10.3892/ijo.2017.3864. Epub 2017 Jan 30. PMID: 28197627.
-
Ding LW, Sun QY, Tan KT, Chien W, Mayakonda A, Yeoh AEJ, Kawamata N, Nagata Y, Xiao JF, Loh XY, Lin DC, Garg M, Jiang YY, Xu L, Lim SL, Liu LZ, Madan V, Sanada M, Fernández LT, Hema Preethi SS, Lill M, Kantarjian HM, Kornblau SM, Miyano S, Liang DC, Ogawa S, Shih LY, Yang H, Koeffler HP. (2017) Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia. Cancer Res. 2017 Jan 15;77(2):390-400. doi: 10.1158/0008-5472.CAN-16-1303. Epub 2016 Nov 21. Erratum in: Cancer Res. 2017 Apr 15;77(8):2174. PMID: 27872090; PMCID: PMC5243866.
-
Hazawa M, Lin DC, Handral H, Xu L, Chen Y, Jiang YY, Mayakonda A, Ding LW, Meng X, Sharma A, Samuel S, Movahednia MM, Wong RW, Yang H, Tong C, Koeffler HP. (2017) ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. Oncogene. 2017 Apr 20;36(16):2243-2254. doi: 10.1038/onc.2016.377. Epub 2016 Nov 7. PMID: 27819679; PMCID: PMC5415641.
-
Ding LW, Ikezoe T, Tan KT, Mori M, Mayakonda A, Chien W, Lin DC, Jiang YY, Lill M, Yang H, Sun QY, Koeffler HP. (2017) Mutational profiling of a MonoMAC syndrome family with GATA2 deficiency. Leukemia. 2017 Jan;31(1):244-245. doi: 10.1038/leu.2016.256. Epub 2016 Sep 29. PMID: 27680514; PMCID: PMC5214977.
-
Sun QY, Ding LW, Tan KT, Chien W, Mayakonda A, Lin DC, Loh XY, Xiao JF, Meggendorfer M, Alpermann T, Garg M, Lim SL, Madan V, Hattori N, Nagata Y, Miyano S, Yeoh AE, Hou HA, Jiang YY, Takao S, Liu LZ, Tan SZ, Lill M, Hayashi M, Kinoshita A, Kantarjian HM, Kornblau SM, Ogawa S, Haferlach T, Yang H, Koeffler HP. (2017) Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD). Leukemia. 2017 Jan;31(1):1-10. doi: 10.1038/leu.2016.160. Epub 2016 Jun 8. PMID: 27389053; PMCID: PMC5214979.
-
Jiang YY, Lin DC, Mayakonda A, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia D, Shang L, Xu X, Yang H, Tyner JW, Wang MR, Koeffler HP. (2017) Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma. Gut. 2017 Aug;66(8):1358-1368. doi:10.1136/gutjnl-2016-311818. Epub 2016 May 10. PMID: 27196599; PMCID: PMC5912916.
-
Hao JJ, Lin DC, Dinh HQ, Mayakonda A, Jiang YY, Chang C, Jiang Y, Lu CC, Shi ZZ, Xu X, Zhang Y, Cai Y, Wang JW, Zhan QM, Wei WQ, Berman BP, Wang MR, Koeffler HP. (2016) Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet. 2016 Dec;48(12):1500-1507. doi: 10.1038/ng.3683. Epub 2016 Oct 17. PMID: 27749841; PMCID: PMC5127772.
-
Sun H, Lin DC, Guo X, Kharabi Masouleh B, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP. (2016) Inhibition of IRE1a-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget. 2016 Apr 5;7(14):18736-49. doi: 10.18632/oncotarget.7702. Erratum in: Oncotarget. 2017 Sep 8;8(38):64651. PMID: 26934650; PMCID: PMC4951325.
-
Sun H, Lin DC, Cao Q, Guo X, Marijon H, Zhao Z, Gery S, Xu L, Yang H, Pang B, Lee VK, Lim HJ, Doan N, Said JW, Chu P, Mayakonda A, Thomas T, Forscher C, Baloglu E, Shacham S, Rajalingam R, Koeffler HP. (2016) CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1-Dependent IGF-1 Signaling. Cancer Res. 2016 May 1;76(9):2687-97. doi: 10.1158/0008-5472.CAN-15-1572. Epub 2016 Mar 8. PMID: 26956669.
-
Cao Q, Gearhart MD, Gery S, Shojaee S, Yang H, Sun H, Lin DC, Bai JW, Mead M, Zhao Z, Chen Q, Chien WW, Alkan S, Alpermann T, Haferlach T, Müschen M, Bardwell VJ, Koeffler HP. (2016) BCOR regulates myeloid cell proliferation and differentiation. Leukemia. 2016 May;30(5):1155-65. doi: 10.1038/leu.2016.2. Epub 2016 Feb 5. PMID: 26847029; PMCID: PMC5131645.
-
Garg M, Nagata Y, Kanojia D, Mayakonda A, Yoshida K, Haridas Keloth S, Zang ZJ, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ding LW, Alpermann T, Sun QY, Lin DC, Chien W, Madan V, Liu LZ, Tan KT, Sampath A, Venkatesan S, Inokuchi K, Wakita S, Yamaguchi H, Chng WJ, Kham SK, Yeoh AE, Sanada M, … Ogawa S, Koeffler HP. (2015) Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse. Blood. 2015 Nov 26;126(22):2491-501. doi: 10.1182/blood-2015-05-646240. Epub 2015 Oct 5. PMID: 26438511; PMCID: PMC4661172.
-
Lin DC*, Xu L, Chen Y, Yan H, Hazawa M, Doan N, Said JW, Ding LW, Liu LZ, Yang H, Yu S, Kahn M, Yin D, Koeffler HP. (2015) Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma. Cancer Res. 2015 May 1;75(9):1815-27. doi:10.1158/0008-5472.CAN-14-1433. Epub 2015 Apr 15. PMID: 25877876; PMCID:PMC4417379.
-
Zhang H, Li W, Huang P, Lin L, Ye H, Lin D, Koeffler HP, Wang J, Yin D. (2015) Expression of CCN family members correlates with the clinical features of hepatocellular carcinoma. Oncol Rep. 2015 Mar;33(3):1481-92. doi: 10.3892/or.2015.3709. Epub 2015 Jan 8. PMID: 25571929.
-
Sun QY, Ding LW, Xiao JF, Chien W, Lim SL, Hattori N, Goodglick L, Chia D, Mah V, Alavi M, Kim SR, Doan NB, Said JW, Loh XY, Xu L, Liu LZ, Yang H, Hayano T, Shi S, Xie D, Lin DC, Koeffler HP. (2015) SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway. J Pathol. 2015 Mar;235(4):559-70. doi:10.1002/path.4482. Epub 2014 Dec 18. PMID: 25404354; PMCID: PMC4333197.
-
Ding LW, Sun QY, Lin DC, Chien W, Hattori N, Dong XM, Gery S, Garg M, Doan NB, Said JW, Xiao JF, Yang H, Liu LZ, Meng X, Huang RY, Tang K, Koeffler HP. (2015) LNK(SH2B3): paradoxical effects in ovarian cancer. Oncogene. 2015 Mar 12;34(11):1463-74. doi: 10.1038/onc.2014.34. Epub 2014 Apr 7. PMID: 24704825; PMCID: PMC4188804.
-
Lin DC, Meng X, Hazawa M, Nagata Y, Varela AM, Xu L, Sato Y, Liu LZ, Ding LW, Sharma A, Goh BC, Lee SC, Petersson BF, Yu FG, Macary P, Oo MZ, Ha CS, Yang H, Ogawa S, Loh KS, Koeffler HP. (2014) The genomic landscape of nasopharyngeal carcinoma. Nat Genet. 2014 Aug;46(8):866-71. doi: 10.1038/ng.3006. Epub 2014 Jun 22. PMID:24952746.
-
Jin S, Wang K, Xu K, Xu J, Sun J, Chu Z, Lin D, Koeffler PH, Wang J, Yin D. (2014) Oncogenic function and prognostic significance of protein tyrosine phosphatase PRL-1 in hepatocellular carcinoma. Oncotarget. 2014 Jun 15;5(11):3685-96. doi:10.18632/oncotarget.1986. PMID: 25003523; PMCID: PMC4116513.
-
Lin DC, Wang MR, Koeffler HP. (2014) Targeting genetic lesions in esophageal cancer. Cell Cycle. 2014;13(13):2013-4. doi: 10.4161/cc.29458. Epub 2014 Jun 5. PMID:24901941; PMCID: PMC4111687.
-
Lin DC, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, Garg M, Liu LZ, Yang H, Yin D, Shi ZZ, Jiang YY, Gu WY, Gong T, Zhang Y, Xu X, Kalid O, Shacham S, Ogawa S, Wang MR, Koeffler HP. (2014) Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet. 2014 May;46(5):467-73. doi: 10.1038/ng.2935. Epub 2014 Mar 30. PMID: 24686850;PMCID: PMC4070589.
-
Xu L, Lin DC, Yin D, Koeffler HP. (2014) An emerging role of PARK2 in cancer. J Mol Med (Berl). 2014 Jan;92(1):31-42. doi: 10.1007/s00109-013-1107-0. Epub 2013 Dec 3. PMID: 24297497.
-
Shi ZZ, Shang L, Jiang YY, Hao JJ, Zhang Y, Zhang TT, Lin DC, Liu SG, Wang BS, Gong T, Zhan QM, Wang MR. (2013) Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization. Clin Cancer Res. 2013 Nov 1;19(21):5867-78. doi: 10.1158/1078-0432.CCR-12-3753. Epub 2013 Sep 5. PMID: 24009147.
-
Koren-Michowitz M, Gery S, Tabayashi T, Lin D, Alvarez R, Nagler A, Koeffler HP. (2013) SH2B3 (LNK) mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F. Br J Haematol. 2013 Jun;161(6):811-20. doi: 10.1111/bjh.12327. Epub 2013 Apr 17. PMID: 23590807;PMCID: PMC3672250.
-
Lin DC, Xu L, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, Urban N, Schummer M, Doan N, Said JW, Sun H, Walsh M, Thomas CJ, Patel P, Yin D, Chan D, Koeffler HP. (2013) Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6109-14. doi: 10.1073/pnas.1218206110. Epub 2013 Mar 27. PMID:23536305; PMCID: PMC3625360.
-
Lin DC, Yin T, Koren-Michowitz M, Ding LW, Gueller S, Gery S, Tabayashi T, Bergholz U, Kazi JU, Rönnstrand L, Stocking C, Koeffler HP. (2012) Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood. 2012 Oct 18;120(16):3310-7. doi: 10.1182/blood-2011-10-388611. Epub 2012 Aug 31. PMID:22942183; PMCID: PMC3476541.
-
Zhang Y, Du XL, Wang CJ, Lin DC, Ruan X, Feng YB, Huo YQ, Peng H, Cui JL, Zhang TT, Wang YQ, Zhang H, Zhan QM, Wang MR. (2012) Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells. Gastroenterology. 2012 Mar;142(3):521-530.e3. doi: 10.1053/j.gastro.2011.11.023. Epub 2011 Nov 19. PMID: 22108192.
-
Lin DC, Zhang Y, Pan QJ, Yang H, Shi ZZ, Xie ZH, Wang BS, Hao JJ, Zhang TT, Xu X, Zhan QM, Wang MR. (2011) PLK1 Is transcriptionally activated by NF-?B during cell detachment and enhances anoikis resistance through inhibiting ß-catenin degradation in esophageal squamous cell carcinoma. Clin Cancer Res. 2011 Jul 1;17(13):4285-95. doi: 10.1158/1078-0432.CCR-10-3236. Epub 2011 May 24. PMID:21610149.
-
Shi ZZ, Liang JW, Zhan T, Wang BS, Lin DC, Liu SG, Hao JJ, Yang H, Zhang Y, Zhan QM, Zhang KT, Wang MR. (2011) Genomic alterations with impact on survival in esophageal squamous cell carcinoma identified by array comparative genomic hybridization. Genes Chromosomes Cancer. 2011 Jul;50(7):518-26. doi:10.1002/gcc.20875. Epub 2011 Apr 11. PMID: 21484929.
-
Liu SG, Wang BS, Jiang YY, Zhang TT, Shi ZZ, Yang Y, Yang YL, Wang XC, Lin DC, Zhang Y, Yang H, Cai Y, Zhan QM, Wang MR. (2011) Atypical protein kinase Cι (PKCι) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCι-SKP2-AKT pathway. Mol Cancer Res. 2011 Apr;9(4):390-402. doi: 10.1158/1541-7786.MCR-10-0359. Epub 2011 Feb 10. PMID: 21310827.
-
Lin DC, Shi ZZ, Xue LY, Chen W, Xu X, Han YL, Lv N, Wang MR. (2010) [Expression of cell cycle related proteins cyclin D1, p53 and p21WAF1/Cip1 in esophageal squamous cell carcinoma]. Yi Chuan. 2010 May;32(5):455-60. Chinese. doi: 10.3724/sp.j.1005.2010.00455. PMID: 20466633.
-
Du XL, Yang H, Liu SG, Luo ML, Hao JJ, Zhang Y, Lin DC, Xu X, Cai Y, Zhan QM, Wang MR. (2009) Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma. Oncogene. 2009 Oct 22;28(42):3714-22. doi: 10.1038/onc.2009.237. Epub 2009 Aug 17. PMID:19684620.
-
Feng YB, Lin DC, Shi ZZ, Wang XC, Shen XM, Zhang Y, Du XL, Luo ML, Xu X, Han YL, Cai Y, Zhang ZQ, Zhan QM, Wang MR. (2009) Overexpression of PLK1 is associated with poor survival by inhibiting apoptosis via enhancement of survivin level in esophageal squamous cell carcinoma. Int J Cancer. 2009 Feb 1;124(3):578-88. doi:10.1002/ijc.23990. PMID: 19004025.
-
Wang XC, Wu YP, Ye B, Lin DC, Feng YB, Zhang ZQ, Xu X, Han YL, Cai Y, Dong JT, Zhan QM, Wu M, Wang MR. (2009) Suppression of anoikis by SKP2 amplification and overexpression promotes metastasis of esophageal squamous cell carcinoma. Mol Cancer Res. 2009 Jan;7(1):12-22. doi: 10.1158/1541-7786.MCR-08-0092. PMID:19147533.
-
Lin DC, Du XL, Wang MR. (2009) Protein alterations in ESCC and clinical implications: a review. Dis Esophagus. 2009;22(1):9-20. doi:10.1111/j.1442-2050.2008.00845.x. Epub 2008 Jun 17. PMID: 18564170.