Smad4-Irf6 genetic interaction and TGFB-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Urata M, Dixon MJ, Chai Y. (2013) Development 140(6): 1220-30….Continue Reading New Article: Smad4-Irf6 genetic interaction and TGFB-mediated IRF6 signaling cascade are crucial for palatal fusion in mice
Month: March 2013
Dynamic imaging
Micro CT and Micro MRI imaging of a mouse skull, showing hard and soft tissue….Continue Reading Dynamic imaging
Stem cell research
Stem cells located near vasculature in the retina. Red: GS-IB4 staining, labeling the endothelium. Green: H2BGFP labeling nuclei derived from neural crest cells. Image from Yang Chai’s lab….Continue Reading Stem cell research
Understanding tooth formation
Polarized odontoblasts (top) and polarized ameloblasts (bottom) forming the initial dentin and enamel during tooth formation. Image from Michael Paine’s lab….Continue Reading Understanding tooth formation
Tooth enamel research
Polished coronal section from a mandibular incisor tooth of a 6-week old transgenic mouse over-expressing dentin sialoprotein in the enamel matrix. The mesial aspect of the tooth is to the top, and the labial aspect is to the right. The junction between the enamel and the underlying dentin (dentino-enamel junction) is clearly evident. Image from…Continue Reading Tooth enamel research
Biomaterials research
Fluorescence microscopy image of periodontal ligament stem cells cultured (14 days) on titanium surfaces coated with amelogenin-apatite nano-composite. Image taken by JinPu Chu, Visiting Scholar in Oldak’s group….Continue Reading Biomaterials research
Understanding enamel formation
Confocal images of mouse mandibular molars showing immunofluorescence of amelogenin (green) and enamelin (red) at postnatal day 3. Co-localization of amelogenin and enamelin is revealed by overlapping signals resulting in yellow/orange staining. Nuclei are stained with DAPI (blue). Image taken by Postdoctoral Associate Victoria Gallon. Scale is 100 microns….Continue Reading Understanding enamel formation
Stem cell research
Whisker pad tissue section. Green: H2BGFP labeling nuclei derived from neural crest cells. Blue: DAPI staining, labeling nuclei of all tissues. Image from Yang Chai’s lab….Continue Reading Stem cell research
Biomaterials science
SEM image shows the morphology of a newly-grown apatite layer formed in chitosan hydrogel without amelogenin after remineralization in an artificial saliva solution for 7 days. Image from Janet Oldak’s lab….Continue Reading Biomaterials science
Tissue regeneration
Immune cells govern cell-based tissue regeneration: MicroCT images showed that mesenchymal stem cells (MSC) failed to repair over-sized calvarial defects (center; no treatment, left). However, infusion of regulatory T cells (Treg) significantly improved MSC-based calvarial regeneration (right)….Continue Reading Tissue regeneration